Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 7/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1621164 | 1.00 | ALDH1A1 (0.38) | ALDH1A1GAACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1619623 | 0.87 | ALDH1A1 (0.39) | ALDH1A1GAAKDRDPP4EGFR | |
| SCHEMBL863038 | 0.87 | ALDH1A1 (0.39) | ALDH1A1GAAKDRDPP4EGFR | |
| SCHEMBL858362 | 0.87 | KDM4E (0.35) | ALDH1A1KDREGFRKDM4ESMN1; SMN2 | |
| SCHEMBL858364 | 0.87 | KDM4E (0.35) | ALDH1A1KDREGFRKDM4ESMN1; SMN2 | |
| SCHEMBL862853 | 0.86 | MAPKAPK2 (0.39) | CYP1A2CYP3A4CYP2C9CYP2C19KDR | |
| SCHEMBL1684000 | 0.84 | KDR (0.38) | ALDH1A1GAACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL18175977 | 0.84 | KDR (0.38) | ALDH1A1GAACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL28801538 | 0.78 | POLB (0.39) | ALDH1A1GAACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL12067848 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143395-B2 | Process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines | DOW AGROSCIENCES LLC (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143395-B2 | Process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines | DOW AGROSCIENCES LLC (US) | 2012-03-27 | — | — | US | disclosed |