Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1619623 | 1.00 | ALDH1A1 (0.39) | ALDH1A1GAADPP4SMN1; SMN2KDM4E | |
| SCHEMBL1621164 | 0.87 | ALDH1A1 (0.38) | ALDH1A1GAADPP4SMN1; SMN2KDM4E | |
| SCHEMBL862858 | 0.87 | ALDH1A1 (0.38) | ALDH1A1GAADPP4SMN1; SMN2KDM4E | |
| SCHEMBL862918 | 0.86 | MAPT (0.39) | ALDH1A1GAADPP4SMN1; SMN2KDM4E | |
| SCHEMBL10037045 | 0.83 | DPP4 (0.38) | ALDH1A1GAADPP4SMN1; SMN2KDM4E | |
| SCHEMBL1619616 | 0.75 | MAPT (0.40) | ALDH1A1GAADPP4SMN1; SMN2KDM4E | |
| SCHEMBL14300726 | 0.74 | EPHX1 (0.37) | ALDH1A1GAASMN1; SMN2KDM4EMAPK3 | |
| SCHEMBL858362 | 0.73 | KDM4E (0.35) | ALDH1A1SMN1; SMN2KDM4EKDRRAB9A | |
| SCHEMBL858364 | 0.73 | KDM4E (0.35) | ALDH1A1SMN1; SMN2KDM4EKDRRAB9A | |
| SCHEMBL862853 | 0.73 | MAPKAPK2 (0.39) | DPP4SMN1; SMN2KDM4EKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143395-B2 | Process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines | DOW AGROSCIENCES LLC (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143395-B2 | Process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines | DOW AGROSCIENCES LLC (US) | 2012-03-27 | — | — | US | disclosed |