Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.35 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16220778 | 0.90 | ALDH1A1 (0.44) | PAX8ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL16212288 | 0.86 | SUV39H2 (0.39) | PAX8ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL16212797 | 0.85 | KDM4E (0.38) | PAX8ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL17626839 | 0.73 | ALDH1A1 (0.51) | ALDH1A1KDM4EPDE10AMEN1KMT2A | |
| SCHEMBL23766607 | 0.71 | GPR119 (0.46) | PAX8GPR119HSD17B10 | |
| SCHEMBL14715354 | 0.70 | PAX8 (0.54) | PAX8MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL846595 | 0.68 | PAX8 (0.51) | PAX8ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL691501 | 0.68 | HCAR3 (0.51) | PAX8ALDH1A1KDM4EMAPTGPR119 | |
| Acetic Acid SCHEMBL17626698 | 0.68 | RAB9A (0.40) | ALDH1A1KDM4EPDE10AMEN1KMT2A | |
| SCHEMBL3296861 | 0.67 | ALDH1A1 (0.53) | ALDH1A1KDM4EMEN1KMT2AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2991983-A1 | 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-03-09 | — | — | EP | disclosed |
| WO-2014177458-A1 | 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-11-06 | — | — | WO | disclosed |