Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP19 | O94966 | 4/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL426697 | 0.77 | FAAH (0.44) | USP19GRIN2BPOLBADORA2AADORA3 | |
| SCHEMBL427489 | 0.73 | FAAH (0.40) | USP19GRIN2BADORA2AADORA3ADORA1 | |
| SCHEMBL2731600 | 0.72 | CYP2A6 (0.56) | — | |
| SCHEMBL15511383 | 0.70 | LMNA (0.33) | POLB | |
| SCHEMBL27859118 | 0.67 | MAOA (0.45) | POLBNPC1MAPT | |
| SCHEMBL29106080 | 0.65 | ACMSD (0.54) | POLBDHODH | |
| SCHEMBL6223694 | 0.65 | KMO (0.54) | ADORA2AADORA3ADORA1ADORA2BNPC1 | |
| SCHEMBL16566651 | 0.64 | PARP1 (0.39) | ADORA2AADORA3ADORA1ADORA2BNPC1 | |
| SCHEMBL6028461 | 0.64 | FAAH (0.47) | GRIN2BADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL4498726 | 0.63 | KDM4C (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2991989-A1 | IMIDAZO-TRIAZINE DERIVATIVES AS PDE10 INHIBITORS | Pfizer Inc. (US) | 2016-03-09 | — | — | EP | disclosed |
| WO-2014177977-A1 | IMIDAZO-TRIAZINE DERIVATIVES AS PDE10 INHIBITORS | PFIZER INC. (US) | 2014-11-06 | — | — | WO | disclosed |