Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13320698 | 0.85 | TRPM2 (0.55) | KDM4ESMN1; SMN2ALDH1A1HDAC3L3MBTL1 | |
| SCHEMBL13352247 | 0.78 | HDAC3 (0.47) | KDM4ESMN1; SMN2ALDH1A1HDAC3L3MBTL1 | |
| SCHEMBL16215191 | 0.77 | TRPM2 (0.60) | KDM4ESMN1; SMN2HTTALDH1A1LMNA | |
| SCHEMBL18362785 | 0.77 | SMN1; SMN2 (0.58) | KDM4ESMN1; SMN2HTTALDH1A1THRB | |
| SCHEMBL16215175 | 0.74 | NPC1 (0.76) | KDM4ESMN1; SMN2ALDH1A1HDAC3LMNA | |
| SCHEMBL16215143 | 0.74 | MMP1 (0.58) | KDM4ESMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL13320688 | 0.73 | TRPA1 (0.60) | KDM4ESMN1; SMN2HTTALDH1A1L3MBTL1 | |
| SCHEMBL16215171 | 0.71 | ALDH1A1 (0.77) | KDM4ESMN1; SMN2ALDH1A1HDAC3LMNA | |
| SCHEMBL16215205 | 0.71 | ALDH1A1 (0.85) | KDM4ESMN1; SMN2HTTALDH1A1HDAC3 | |
| SCHEMBL16215255 | 0.70 | ALDH1A1 (0.71) | KDM4ESMN1; SMN2ALDH1A1HDAC3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2799427-A1 | Therapeutic compounds | Fibrotech Therapeutics PTY LTD (AU) | 2014-11-05 | — | — | EP | disclosed |