SCHEMBL16410980

Cc1cn([C@H]2C[C@@H](OP(=O)(S)OC[C@@H]3CC[C@H](n4cnc5c(N)ncnc54)O3)[C@@H](COP(=O)(O)S)O2)c(=O)nc1N

nearest known ligand 0.54

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	POLB	P06746	1/20	0.47

▸	DTYMK	P23919	4/20	0.46

▸	P2RY1	P47900	2/20	0.45

▸	ENPP1	P22413	2/20	0.45

▸	BCHE	P06276	1/20	0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL16217855	0.94	TERT (0.50)	POLBDTYMKP2RY1
SCHEMBL22352121	0.92	POLB (0.54)	POLBP2RY1ENPP1
SCHEMBL20763160	0.92	POLB (0.54)	POLBP2RY1ENPP1
SCHEMBL18158887	0.90	DTYMK (0.58)	POLBDTYMK
SCHEMBL18158882	0.90	DTYMK (0.58)	POLBDTYMK
SCHEMBL24239532	0.90	DTYMK (0.58)	POLBDTYMK
SCHEMBL17231124	0.90	TK1 (0.39)	POLBP2RY1
SCHEMBL16221824	0.89	POLB (0.50)	POLBP2RY1
SCHEMBL18158912	0.89	POLB (0.50)	POLBP2RY1
SCHEMBL25967106	0.88	POLB (0.53)	POLBP2RY1ENPP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2015010135-A2	COMPOSITIONS FOR MODULATING TAU EXPRESSION	ISIS PHARMACEUTICALS, INC. (US)	2015-01-22	—	—	WO	disclosed