Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 2/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | MGAT3 | Q09327 | 1/20 | 0.32 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 4/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229782 | 0.93 | SLC6A9 (0.39) | SLC6A9KCNH2HTR6KMT2A | |
| SCHEMBL16229756 | 0.92 | SLC6A9 (0.32) | SLC6A9KCNH2 | |
| SCHEMBL16229762 | 0.92 | KMT2A (0.32) | SLC6A9HTR2AHTR2CKMT2ASMYD3 | |
| SCHEMBL16229802 | 0.91 | GALR3 (0.38) | SLC6A9TRPV1 | |
| SCHEMBL16229785 | 0.89 | DGAT1 (0.36) | SLC6A9DGAT1MGAT3MGAT2KCNH2 | |
| SCHEMBL16229754 | 0.87 | RORC (0.32) | DGAT1MGAT3MGAT2HTR2AHTR2C | |
| SCHEMBL16784625 | 0.87 | SLC6A9 (0.39) | SLC6A9HTR2AKCNH2HTR6 | |
| SCHEMBL16784629 | 0.84 | LMNA (0.36) | SLC6A9KCNH2KMT2A | |
| SCHEMBL16784642 | 0.84 | SLC6A9 (0.35) | SLC6A9KCNH2KMT2ASMYD3 | |
| SCHEMBL16229764 | 0.84 | KMT2A (0.32) | SLC6A9KMT2ASMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |