Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229754 | 0.92 | RORC (0.32) | RORC | |
| SCHEMBL16229784 | 0.92 | DPP4 (0.34) | DPP4DPP8DPP9DPP7RORC | |
| SCHEMBL16229778 | 0.91 | NR1D1 (0.33) | PKM | |
| SCHEMBL16229795 | 0.89 | GALR3 (0.35) | DPP4SLC6A9NPC1PKM | |
| SCHEMBL16229805 | 0.88 | SLC6A9 (0.38) | DPP4DPP8DPP9DPP7SCN9A | |
| SCHEMBL16229756 | 0.88 | SLC6A9 (0.32) | RORCSLC6A9 | |
| SCHEMBL16229776 | 0.87 | SLC6A9 (0.36) | DPP4DPP8DPP9DPP7CNR1 | |
| SCHEMBL16229759 | 0.84 | RORC (0.33) | RORC | |
| SCHEMBL16229761 | 0.83 | SLC6A9 (0.37) | SLC6A9TP53 | |
| SCHEMBL16784638 | 0.83 | LMNA (0.34) | SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |