SCHEMBL16233166

SCHEMBL16233166

COc1cc(C(=O)CO)cc(OC)c1OCc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.58
NPC1 O15118 1/20 0.58
RAB9A P51151 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
SLC6A5 Q9Y345 3/20 0.54
SMPD1 P17405 1/20 0.53
HDAC1 Q13547 1/20 0.53
HDAC8 Q9BY41 1/20 0.53
HDAC6 Q9UBN7 1/20 0.53
LMNA P02545 1/20 0.52
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
MRGPRX4 Q96LA9 1/20 0.50
RXRA P19793 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.49
ATM Q13315 1/20 0.49
MGAM O43451 1/20 0.48
GAA P10253 1/20 0.48
SI P14410 1/20 0.48
MGAM2 Q2M2H8 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8843690 0.89 SMN1; SMN2 (0.73) HPGDNPC1RAB9ASMN1; SMN2SLC6A5
SCHEMBL2317454 0.87 RXRA (0.61) HPGDNPC1RAB9ASMN1; SMN2SLC6A5
Hydrochloric Acid SCHEMBL16143333 0.85 RXRA (0.60) HPGDNPC1RAB9ASMN1; SMN2SLC6A5
SCHEMBL10429197 0.84 GLRA1 (0.64) HPGDNPC1RAB9ASMN1; SMN2SLC6A5
SCHEMBL5240840 0.84 HPGD (0.74) HPGDNPC1RAB9ASMN1; SMN2SLC6A5
SCHEMBL15673277 0.84 RXRA (0.62) HPGDNPC1RAB9ASMN1; SMN2SLC6A5
SCHEMBL7082122 0.84 KDM4E (0.64) HPGDNPC1RAB9ASMN1; SMN2SLC6A5
SCHEMBL9680615 0.83 HPGD (0.58) HPGDNPC1RAB9ASMN1; SMN2SLC6A5
Hydrochloric Acid SCHEMBL31692073 0.83 KDM4E (0.63) HPGDNPC1RAB9ASMN1; SMN2SLC6A5
SCHEMBL10998628 0.82 CTSV (0.49) HPGDNPC1RAB9ASMN1; SMN2SMPD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9359346-B2 Benzamide derivative and use thereof VIVOZON, INC. (KR) 2016-06-07 US disclosed
US-20140336378-A1 NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF VIVOZON, INC. (KR) 2014-11-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140336378-A1 NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF TRPV1, TRPA1, TRPV5 HPGD 1066/4885NPC1 783/4885RAB9A 1568/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.