Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444239 | 0.84 | PDE4D (0.54) | CTSVCTSLPDE4DHPGDNPC1 | |
| SCHEMBL16233166 | 0.82 | HPGD (0.58) | MGAMGAASIMGAM2HPGD | |
| SCHEMBL10992318 | 0.81 | KDM4E (0.49) | PDE4DRAB9ASMN1; SMN2 | |
| SCHEMBL6762318 | 0.80 | CTSV (0.52) | CTSVCTSLHPGDLMNAMRGPRX4 | |
| SCHEMBL8318992 | 0.79 | ALDH1A1 (0.49) | PDE4DGAAHPGDNPC1RAB9A | |
| SCHEMBL8052932 | 0.76 | SMN1; SMN2 (0.53) | CTSVCTSLPDE4DMGAMGAA | |
| SCHEMBL5465796 | 0.75 | CTSV (0.48) | CTSVCTSLPDE4DHPGDNPC1 | |
| SCHEMBL28133879 | 0.75 | PDE4D (0.62) | CTSVCTSLPDE4DHPGDNPC1 | |
| SCHEMBL24140919 | 0.75 | MRGPRX4 (0.51) | CTSVCTSLHPGDNPC1RAB9A | |
| SCHEMBL9729812 | 0.75 | LRRK2 (0.57) | CTSVCTSLGAAHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4532254-A | Inhibitor of aldose reductase | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1985-07-30 | — | — | US | disclosed |