SCHEMBL16233236

SCHEMBL16233236

CCCCOc1c(OC)cc(C(=O)N2CCN(CCc3ccccc3)CC2)cc1OC

nearest known ligand 0.63

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.61
KMT2A Q03164 2/20 0.61
POLB P06746 2/20 0.60
GAA P10253 1/20 0.60
KCNH2 Q12809 1/20 0.57
THRB P10828 1/20 0.57
ALDH1A1 P00352 3/20 0.55
CYP1A2 P05177 1/20 0.55
SLC29A1 Q99808 1/20 0.54
KDM4E B2RXH2 1/20 0.52
LMNA P02545 1/20 0.52
DRD3 P35462 3/20 0.52
DRD2 P14416 2/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
SIGMAR1 Q99720 1/20 0.51
KCNA5 P22460 1/20 0.51
TLR9 Q9NR96 1/20 0.51
TLR8 Q9NR97 1/20 0.51
TLR7 Q9NYK1 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16233212 0.89 POLB (0.64) MEN1KMT2APOLBGAAKCNH2
SCHEMBL9515518 0.88 ALDH1A1 (0.70) MEN1KMT2APOLBGAAKCNH2
SCHEMBL16233183 0.84 ALDH1A1 (0.54) MEN1KMT2APOLBGAAALDH1A1
SCHEMBL9512949 0.82 KMT2A (0.83) MEN1KMT2APOLBGAAKCNH2
SCHEMBL31178415 0.82 KMT2A (0.83) MEN1KMT2APOLBGAAKCNH2
SCHEMBL25242104 0.78 KMT2A (0.77) MEN1KMT2APOLBGAAKCNH2
SCHEMBL31178346 0.78 KMT2A (0.77) MEN1KMT2APOLBGAAKCNH2
SCHEMBL25284686 0.78 DRD2 (0.75) MEN1KMT2APOLBGAAKCNH2
SCHEMBL25286763 0.78 KMT2A (0.96) MEN1KMT2APOLBGAAALDH1A1
SCHEMBL31178374 0.78 KMT2A (0.96) MEN1KMT2APOLBGAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9359346-B2 Benzamide derivative and use thereof VIVOZON, INC. (KR) 2016-06-07 US disclosed
US-9359346-B2 Benzamide derivative and use thereof VIVOZON, INC. (KR) 2016-06-07 US disclosed
US-20140336378-A1 NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF VIVOZON, INC. (KR) 2014-11-13 US disclosed
US-20140336378-A1 NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF VIVOZON, INC. (KR) 2014-11-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140336378-A1 NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF TRPV1, TRPA1, TRPV5 MEN1 4781/4885KMT2A 1068/4885POLB 3592/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.