Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.49 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052901 | 0.77 | JMJD6 (0.52) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL25343055 | 0.77 | KMT2A (0.64) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL20767134 | 0.76 | JMJD6 (0.44) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL8221283 | 0.74 | PKM (0.51) | ALDH1A1KMT2AKDM4ETSHRJMJD6 | |
| SCHEMBL15279104 | 0.73 | ALDH1A1 (0.57) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL31474370 | 0.73 | JMJD6 (0.52) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL8121938 | 0.72 | ALDH1A1 (0.60) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL2742976 | 0.72 | HCAR2 (0.54) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL10406368 | 0.72 | KMT2A (0.49) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL4258913 | 0.72 | PKM (0.43) | ALDH1A1KMT2AMEN1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116494-B1 | PYRIDAZINE DERIVATIVES WITH A PSYCHOTROPE ACTIVITY, PROCESS FOR THEIR PREPARATION, INTERMEDIATES AND MEDICINES CONTAINING THEM | SANOFI S.A. (FR) | 1988-01-27 | — | — | EP | claimed |
| EP-4323066-A1 | MEK INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |
| US-20230382864-A1 | PYRIDINONE MK2 INHIBITORS AND USES THEREOF | XINTHERA, INC. | 2023-11-30 | — | — | US | disclosed |
| US-20230382864-A1 | PYRIDINONE MK2 INHIBITORS AND USES THEREOF | XINTHERA, INC. | 2023-11-30 | — | — | US | disclosed |
| US-11685719-B2 | Pyridinone MK2 inhibitors and uses thereof | XINTHERA, INC. (US) | 2023-06-27 | — | — | US | disclosed |
| US-11685719-B2 | Pyridinone MK2 inhibitors and uses thereof | XINTHERA, INC. (US) | 2023-06-27 | — | — | US | disclosed |
| US-20230053465-A1 | PYRIDINONE MK2 INHIBITORS AND USES THEREOF | XINTHERA, INC. | 2023-02-23 | — | — | US | disclosed |
| WO-2023283338-A1 | PYRIDINONE MK2 INHIBITORS AND USES THEREOF | XINTHERA, INC. (US) | 2023-01-12 | — | — | WO | disclosed |
| WO-2022221866-A1 | MEK INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-10-20 | — | — | WO | disclosed |
| US-7928106-B2 | 2-[2-(2,5-Difluoro-phenyl)-ethoxymethyl]-3H-pteridin-4-one; 2-2-(3-Fluoro-phenyl)-ethoxymethyl]-3H-pyrimido[4,5-d]pyrimidin-4-one; (5-Oxo-5,6-dihydro-pyrimido[4,5-c]pyridazin-7-ylmethyl)-carbamic acid benzyl ester, useful in treating diseases which are modulated by HM74A agonists e.g. dyslipidemia | HOFFMANN-LA ROCHE INC. (US) | 2011-04-19 | — | — | US | disclosed |
| EP-2139895-A1 | AZA-PYRIDOPYRIMIDINONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116742-A1 | AZA-PYRIDOPYRIMIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-02 | — | — | WO | disclosed |
| US-20080234277-A1 | NOVEL AZA-PYRIDOPYRIMIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230053465-A1 | PYRIDINONE MK2 INHIBITORS AND USES THEREOF | ENPP2, PLP2, PDXK | ALDH1A1 2928/4885KMT2A 791/4885MEN1 1179/4885 |
| US-20230382864-A1 | PYRIDINONE MK2 INHIBITORS AND USES THEREOF | ENPP2, PLP2, PDXK | ALDH1A1 2928/4885KMT2A 791/4885MEN1 1179/4885 |
| US-20080234277-A1 | NOVEL AZA-PYRIDOPYRIMIDINONE DERIVATIVES | CHRM1, CHRM2, CHRM4 | ALDH1A1 543/4885KMT2A 893/4885MEN1 1109/4885 |
| US-11685719-B2 | Pyridinone MK2 inhibitors and uses thereof | ENPP2, PLP2, PDXK | ALDH1A1 2928/4885KMT2A 791/4885MEN1 1179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.