Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.65 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10222047 | 0.88 | MTNR1A (0.61) | MTNR1AMTNR1BHTR2AHTR2CMCL1 | |
| SCHEMBL6099343 | 0.87 | MTNR1A (0.60) | MTNR1AMTNR1BHTR2AHTR2CMCL1 | |
| SCHEMBL11984620 | 0.85 | MTNR1A (0.63) | MTNR1AMTNR1BHTR2AHTR2CMCL1 | |
| SCHEMBL10165374 | 0.84 | MTNR1A (0.57) | MTNR1AMTNR1BHTR2AHTR2CMCL1 | |
| SCHEMBL10204441 | 0.81 | MTNR1A (0.55) | MTNR1AMTNR1BHTR2AHTR2CMCL1 | |
| SCHEMBL980885 | 0.79 | HTR2C (0.65) | MTNR1AMTNR1BHTR2AHTR2CMCL1 | |
| SCHEMBL16543633 | 0.78 | ALDH1A1 (0.48) | MTNR1AMTNR1BKDM4ESMN1; SMN2LMNA | |
| SCHEMBL13139567 | 0.78 | NTSR1 (0.45) | MTNR1AMTNR1BHTR2AHTR2CKDM4E | |
| SCHEMBL12605655 | 0.78 | FKBP1A (0.53) | MTNR1AMTNR1BHTR2AHTR2CHTR7 | |
| SCHEMBL9701534 | 0.77 | KMT2A (0.71) | HTR2AHTR2CHDAC8HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883766-B2 | Ion channel modulators and methods of use | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-11-11 | — | — | US | disclosed |