SCHEMBL16236158

SCHEMBL16236158

COC(=O)c1cc2cccc(Cl)c2[nH]1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 1/20 0.56
CDK1 P06493 1/20 0.54
CCNB1 P14635 1/20 0.54
ABL1 P00519 4/20 0.52
SRC P12931 4/20 0.52
DAO P14920 1/20 0.50
GLA P06280 1/20 0.49
GAA P10253 1/20 0.49
XDH P47989 3/20 0.49
NR4A2 P43354 1/20 0.49
DRD2 P14416 1/20 0.47
DRD3 P35462 1/20 0.47
PYGL P06737 1/20 0.46
PYGM P11217 1/20 0.46
CA12 O43570 1/20 0.44
CA9 Q16790 1/20 0.44
MAP3K5 Q99683 1/20 0.43
SYK P43405 1/20 0.43
NSD2 O96028 1/20 0.43
CYP1A2 P05177 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6307061 0.84 CDK1 (0.75) HRH4CDK1CCNB1DAOGLA
SCHEMBL10509208 0.83 XDH (0.50) HRH4ABL1SRCDAOGLA
SCHEMBL3283667 0.83 NSD2 (0.61) HRH4ABL1SRCDAOGLA
SCHEMBL27337665 0.82 HRH4 (0.59) HRH4CDK1CCNB1DAODRD2
SCHEMBL5355599 0.81 GLA (0.68) HRH4ABL1SRCGLAGAA
SCHEMBL18512251 0.81 XDH (0.64) HRH4ABL1SRCGLAGAA
SCHEMBL6321559 0.81 HRH4 (0.56) HRH4ABL1SRCGLAGAA
SCHEMBL24019959 0.81 ALOX15 (0.57) HRH4CDK1CCNB1DAODRD2
SCHEMBL1144741 0.80 HPGD (0.60) HRH4CDK1CCNB1DAOPYGL
SCHEMBL30305564 0.80 HRH4 (0.57) HRH4CDK1CCNB1DAODRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4370207-B1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES INC (US) 2025-12-17 EP disclosed
US-20240368137-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. 2024-11-07 US disclosed
US-12012398-B2 Bicyclic compounds as androgen receptor modulators NIDO BIOSCIENCES, INC. (US) 2024-06-18 US disclosed
EP-4370207-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS Nido Biosciences, Inc. (US) 2024-05-22 EP disclosed
US-20230039586-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. 2023-02-09 US disclosed
WO-2023287704-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. (US) 2023-01-19 WO disclosed
US-10189838-B2 Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection HOFFMAN-LA ROCHE INC. (US) 2019-01-29 US disclosed
US-20180072726-A9 NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION HOFFMANN-LA ROCHE INC. (US) 2018-03-15 US disclosed
EP-2997028-A1 AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION F.HOFFMANN-LA ROCHE AG (CH) 2016-03-23 EP disclosed
US-20160068531-A1 NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION HOFFMANN-LA ROCHE INC. (US) 2016-03-10 US disclosed
WO-2014184163-A1 AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION F. HOFFMANN-LA ROCHE AG (CH) 2014-11-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230039586-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 HRH4 2810/4885CDK1 839/4885CCNB1 2518/4885
US-20160068531-A1 NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION ZC3HAV1, IDO1, AZI2 HRH4 417/4885CDK1 131/4885CCNB1 52/4885
US-20240368137-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 HRH4 2810/4885CDK1 839/4885CCNB1 2518/4885
US-12012398-B2 Bicyclic compounds as androgen receptor modulators AR, FSHR, NCOA3 HRH4 2422/4885CDK1 902/4885CCNB1 2647/4885
US-20180072726-A9 NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION ZC3HAV1, IDO1, AZI2 HRH4 417/4885CDK1 131/4885CCNB1 52/4885
US-10189838-B2 Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection IDO1, ZC3HAV1, AZI2 HRH4 371/4885CDK1 149/4885CCNB1 47/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.