Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.83 |
| ▸ | MEN1 | O00255 | 7/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.83 |
| ▸ | TP53 | P04637 | 6/20 | 0.83 |
| ▸ | MAPT | P10636 | 6/20 | 0.83 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.83 |
| ▸ | HPGD | P15428 | 5/20 | 0.83 |
| ▸ | LMNA | P02545 | 3/20 | 0.83 |
| ▸ | CASP1 | P29466 | 3/20 | 0.83 |
| ▸ | CASP7 | P55210 | 3/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.71 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | ST6GAL1 | P15907 | 1/20 | 0.71 |
| ▸ | CDK2 | P24941 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 3-Hydroxy-3',4'-Dimethoxyflavone SCHEMBL15676607 | 0.91 | KDM4E (1.00) | KDM4ECYP3A4MEN1KMT2ATP53 | |
| 3-Hydroxy-3',4'-Dimethoxyflavone SCHEMBL30139617 | 0.91 | KDM4E (1.00) | KDM4ECYP3A4MEN1KMT2ATP53 | |
| 3-Hydroxy-3',4'-Dimethoxyflavone SCHEMBL4285872 | 0.91 | KDM4E (1.00) | KDM4ECYP3A4MEN1KMT2ATP53 | |
| SCHEMBL15844041 | 0.90 | KDM4E (0.83) | KDM4ECYP3A4MEN1KMT2ATP53 | |
| SCHEMBL28610828 | 0.88 | KDM4E (0.65) | KDM4ECYP3A4MEN1KMT2ATP53 | |
| SCHEMBL4101098 | 0.86 | ABCB1 (0.84) | KDM4ECYP3A4MEN1KMT2ATP53 | |
| SCHEMBL14259686 | 0.86 | TUBB4A (0.71) | KDM4ECYP3A4MEN1KMT2ATP53 | |
| SCHEMBL12590664 | 0.85 | MAPT (0.84) | KDM4ECYP3A4MEN1KMT2ATP53 | |
| SCHEMBL31031153 | 0.85 | KDM4E (0.80) | KDM4ECYP3A4MEN1KMT2ATP53 | |
| SCHEMBL14764381 | 0.85 | CYP1A1 (0.76) | KDM4ECYP3A4MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2999467-B1 | USE OF A COMBINATION OF TWO COMPOUNDS FOR THE TREATMENT AND/OR PREVENTION OF BONE DISORDERS | INST NAT DE LA RECH AGRONOMIQUE INRA (FR) | 2020-01-08 | — | — | EP | disclosed |
| EP-2999467-A1 | USE OF A COMBINATION OF TWO COMPOUNDS FOR THE TREATMENT AND/OR PREVENTION OF BONE DISORDERS | Institut National De La Recherche Agronomique (INRA) (FR) | 2016-03-30 | — | — | EP | disclosed |
| WO-2014184484-A1 | USE OF A COMBINATION OF TWO COMPOUNDS FOR THE TREATMENT AND/OR PREVENTION OF BONE DISORDERS | INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (FR) | 2014-11-20 | — | — | WO | disclosed |