Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | MARK3 | P27448 | 1/20 | 0.32 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239675 | 0.89 | HTR6 (0.35) | SLC22A12SLC40A1 | |
| SCHEMBL16239521 | 0.85 | KEAP1 (0.42) | PLA2G7NR3C1ADRA2AADRA1AL3MBTL1 | |
| SCHEMBL16239732 | 0.84 | KDM4E (0.36) | PLA2G7NR3C1ADRA2AADRA1AL3MBTL1 | |
| SCHEMBL16239481 | 0.81 | BRD4 (0.36) | CSNK2A2 | |
| SCHEMBL2135919 | 0.78 | PARP14 (0.38) | NR3C1SLC22A12 | |
| SCHEMBL16239957 | 0.74 | MCOLN2 (0.39) | KEAP1SLC40A1 | |
| SCHEMBL16239989 | 0.73 | IMPDH2 (0.40) | PLA2G7L3MBTL1KEAP1 | |
| SCHEMBL2135562 | 0.73 | KDM4E (0.34) | NR3C1ADRA2AKEAP1 | |
| SCHEMBL16240077 | 0.73 | TSHR (0.38) | SLC40A1 | |
| SCHEMBL2134874 | 0.72 | HTT (0.37) | NR3C1ADRA2ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630124-B1 | TETRAHYDROQUINOLINE DERIVATIVES USED AS AMPK ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2014-11-19 | — | — | EP | claimed |