Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.56 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.56 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.56 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365645 | 1.00 | ALDH1A1 (0.70) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL364340 | 0.89 | RXRA (0.62) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL366081 | 0.88 | MAOA (0.63) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL366812 | 0.88 | MAOB (0.63) | ALDH1A1MAPTHTTMAPK1ADAM17 | |
| SCHEMBL365210 | 0.88 | MAOA (0.63) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL365173 | 0.87 | MAOB (0.61) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL364835 | 0.87 | SMPD1 (0.60) | ALDH1A1MAPTHTTPOLBSMPD1 | |
| SCHEMBL7985093 | 0.87 | CA1 (0.67) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL366713 | 0.86 | RAB9A (0.57) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL16239638 | 0.85 | RAB9A (0.62) | ALDH1A1MAPTHTTRAB9ASMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593428-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |