Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | CASP3 | P42574 | 2/20 | 0.67 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.67 |
| ▸ | RXRA | P19793 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.51 |
| ▸ | TUBB | P07437 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16240302 | 0.84 | MRGPRX4 (0.61) | KDM4EMAPTALDH1A1RAB9AKMT2A | |
| SCHEMBL680720 | 0.84 | EZH2 (0.58) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL365645 | 0.81 | ALDH1A1 (0.70) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL16239768 | 0.81 | ALDH1A1 (0.70) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL16239902 | 0.81 | HDAC6 (0.56) | KDM4EMAPTALDH1A1RXRAMEN1 | |
| SCHEMBL365173 | 0.80 | MAOB (0.61) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL679939 | 0.80 | MEN1 (0.60) | ALDH1A1RAB9AMEN1KMT2ASCN9A | |
| SCHEMBL365920 | 0.80 | RORC (0.62) | ALDH1A1NPC1RAB9AATMMEN1 | |
| SCHEMBL364835 | 0.80 | SMPD1 (0.60) | MAPTALDH1A1KMT2AHDAC1SMPD1 | |
| SCHEMBL20773000 | 0.79 | MRGPRX4 (0.48) | KDM4EMAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593428-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |