Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.50 |
| ▸ | SCD | O00767 | 2/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239959 | 0.81 | KDM4E (0.71) | HDAC6MRGPRX4SCN9ARXRASCN5A | |
| SCHEMBL364759 | 0.81 | MRGPRX4 (0.64) | HDAC6MRGPRX4HPGDSCN9ARXRA | |
| SCHEMBL20773000 | 0.79 | MRGPRX4 (0.48) | HDAC6MRGPRX4HPGDGRM2ALDH1A1 | |
| SCHEMBL14890492 | 0.78 | MAOA (0.52) | MRGPRX4SCN9ASCN5A | |
| SCHEMBL364527 | 0.78 | SCN9A (0.63) | HDAC6MRGPRX4HPGDSCN9ARXRA | |
| SCHEMBL365115 | 0.78 | RXRA (0.64) | MRGPRX4SCN9ARXRARXRBPOLB | |
| SCHEMBL366081 | 0.77 | MAOA (0.63) | SCN9ASCN5AALDH1A1MEN1KMT2A | |
| SCHEMBL365210 | 0.77 | MAOA (0.63) | SCN9ASCN5AALDH1A1MEN1KMT2A | |
| SCHEMBL16240196 | 0.77 | SCN9A (0.77) | MRGPRX4SCN9ASCN5AALDH1A1MAPT | |
| SCHEMBL16240302 | 0.76 | MRGPRX4 (0.61) | HDAC6MRGPRX4HPGDSCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593428-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |