Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.61 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.58 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.58 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364759 | 0.88 | MRGPRX4 (0.64) | MRGPRX4HDAC1HDAC8HDAC6SCN9A | |
| SCHEMBL16239959 | 0.84 | KDM4E (0.71) | MRGPRX4HDAC1HDAC8HDAC6SCN9A | |
| SCHEMBL364527 | 0.83 | SCN9A (0.63) | MRGPRX4HDAC1HDAC8HDAC6SCN9A | |
| Diethylamine SCHEMBL16239865 | 0.83 | MRGPRX4 (0.58) | MRGPRX4HDAC1HDAC8HDAC6SCN9A | |
| SCHEMBL678799 | 0.82 | SCN9A (0.56) | SCN9ASCN5AKMT2A | |
| SCHEMBL14890406 | 0.81 | ALDH1A1 (0.53) | HDAC8SCN9ASCN5AMAPTALDH1A1 | |
| SCHEMBL366081 | 0.80 | MAOA (0.63) | SCN9ASCN5ARAB9AMAPTALDH1A1 | |
| SCHEMBL365210 | 0.80 | MAOA (0.63) | SCN9ASCN5ARAB9AMAPTALDH1A1 | |
| SCHEMBL367120 | 0.79 | HDAC8 (0.55) | MRGPRX4HDAC1HDAC8HDAC6SCN9A | |
| SCHEMBL365115 | 0.79 | RXRA (0.64) | MRGPRX4SCN9ASMPD1RAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593428-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |