Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 8/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | LPL | P06858 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9986887 | 0.91 | KEAP1 (0.43) | KEAP1NFE2L2KCNA5CA1CA2 | |
| SCHEMBL14934909 | 0.87 | KEAP1 (0.55) | KEAP1NFE2L2CA1CA2CA9 | |
| SCHEMBL16030765 | 0.87 | KEAP1 (0.55) | KEAP1NFE2L2CA1CA2CA9 | |
| SCHEMBL6989373 | 0.81 | KCNA5 (0.57) | KEAP1NFE2L2KCNA5PLAUKCNK3 | |
| SCHEMBL28659356 | 0.81 | CA1 (0.55) | KEAP1NFE2L2KCNA5CA1CA2 | |
| SCHEMBL25217470 | 0.81 | L3MBTL1 (0.42) | KEAP1NFE2L2KCNA5PLAULIPG | |
| SCHEMBL29707329 | 0.80 | CA2 (0.52) | KEAP1NFE2L2CA1CA2CA9 | |
| SCHEMBL29707332 | 0.80 | CA2 (0.52) | KEAP1NFE2L2CA1CA2CA9 | |
| SCHEMBL24142282 | 0.79 | LIPG (0.54) | KEAP1NFE2L2CA1CA2CA9 | |
| SCHEMBL30543686 | 0.77 | HTT (0.51) | KEAP1NFE2L2CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889638-B2 | Stimulus-triggered prodrugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-11-18 | — | — | US | disclosed |