Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16249707 | 0.86 | GPR119 (0.46) | GPR119CYP2C9MEN1KMT2AGPR174 | |
| SCHEMBL16249710 | 0.83 | GPR119 (0.45) | GPR119ALDH1A1LMNAMAPT | |
| SCHEMBL30772278 | 0.73 | MAPT (0.49) | GPR119ALDH1A1LMNAMAPT | |
| SCHEMBL12465843 | 0.73 | MAPT (0.49) | GPR119ALDH1A1LMNAMAPT | |
| SCHEMBL12465844 | 0.73 | MAPT (0.49) | GPR119ALDH1A1LMNAMAPT | |
| SCHEMBL8409617 | 0.73 | GPR119 (0.50) | GPR119CYP2C9ALDH1A1LMNAMAPT | |
| SCHEMBL16249704 | 0.72 | GPR119 (0.51) | GPR119CYP2C9MEN1KMT2A | |
| SCHEMBL13060194 | 0.72 | GPR119 (0.52) | GPR119CYP2C9MEN1KMT2ADPP4 | |
| SCHEMBL16286344 | 0.72 | MET (0.45) | GPR119USP30 | |
| SCHEMBL2575424 | 0.72 | MET (0.45) | GPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889684-B2 | Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-8889684-B2 | Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-18 | — | — | US | disclosed |