Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16249705 | 0.86 | GPR119 (0.43) | GPR119CYP2C9GPR174ALDH1A1MAPT | |
| SCHEMBL16249703 | 0.81 | GPR119 (0.47) | GPR119ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16249704 | 0.79 | GPR119 (0.51) | GPR119CYP2C9MEN1KMT2A | |
| SCHEMBL8409617 | 0.77 | GPR119 (0.50) | GPR119CYP2C9ALDH1A1MAPT | |
| SCHEMBL16249706 | 0.77 | GPR119 (0.46) | GPR119CYP2C9MEN1KMT2A | |
| SCHEMBL13060194 | 0.77 | GPR119 (0.52) | GPR119CYP2C9SMN1; SMN2MEN1KMT2A | |
| SCHEMBL16249708 | 0.76 | MAPT (0.36) | CYP2C9ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1463154 | 0.75 | MAPT (0.43) | GPR119GPR174ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1463152 | 0.75 | MAPT (0.45) | GPR119GPR174ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11164437 | 0.74 | USP30 (0.47) | GPR119ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670749-B1 | NEW AZAINDOLYLPHENYL SULFONAMIDES AS SERINE/THREONINE KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2016-01-27 | — | — | EP | disclosed |
| US-8889684-B2 | Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-8889684-B2 | Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-18 | — | — | US | disclosed |