Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16249711 | 0.82 | GPR119 (0.46) | GPR119JAK1 | |
| SCHEMBL16249700 | 0.80 | GPR119 (0.44) | GPR119JAK1 | |
| SCHEMBL16249704 | 0.79 | GPR119 (0.51) | GPR119CYP2C9MEN1KMT2A | |
| SCHEMBL16249707 | 0.77 | GPR119 (0.46) | GPR119CYP2C9MEN1KMT2A | |
| SCHEMBL13060194 | 0.77 | GPR119 (0.52) | GPR119CYP2C9MEN1KMT2A | |
| SCHEMBL16249709 | 0.74 | JAK1 (0.49) | GPR119JAK1 | |
| SCHEMBL30659252 | 0.74 | GPR119 (0.49) | GPR119JAK1 | |
| SCHEMBL31442816 | 0.74 | GPR119 (0.49) | GPR119JAK1 | |
| SCHEMBL23029209 | 0.73 | JAK1 (0.75) | JAK1 | |
| SCHEMBL7480263 | 0.73 | GPR119 (0.44) | GPR119CYP2C9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889684-B2 | Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-8889684-B2 | Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-18 | — | — | US | disclosed |