Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28370082 | 1.00 | LMNA (0.51) | LMNAPKMTSHRALDH1A1MAPT | |
| SCHEMBL24620659 | 0.94 | MAPT (0.47) | LMNATSHRALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL25954142 | 0.94 | MAPT (0.47) | LMNATSHRALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL20643563 | 0.88 | MAPT (0.44) | LMNAALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL1793404 | 0.88 | MAPT (0.46) | LMNAPKMTSHRALDH1A1MAPT | |
| SCHEMBL10018215 | 0.87 | TP53 (0.50) | LMNAPKMALDH1A1MAPTNPC1 | |
| SCHEMBL1962637 | 0.87 | AKR1C3 (0.49) | LMNAALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL3143230 | 0.86 | RAB9A (0.46) | LMNAPKMTSHRALDH1A1MAPT | |
| SCHEMBL21940997 | 0.86 | RAB9A (0.46) | LMNAPKMTSHRALDH1A1MAPT | |
| SCHEMBL25954146 | 0.85 | SLC13A5 (0.43) | LMNAALDH1A1MAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 158 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313996-B1 | INDENONAPHTHOPYRANS HAVING TRIALKYLSILYL AND ETHYLENICALLY UNSATURATED GROUPS | TRANSITIONS OPTICAL LTD (IE) | 2026-05-06 | — | — | EP | disclosed |
| US-20240376132-A1 | Indenonaphthopyrans Having Trialkylsilyl and Ethylenically Unsaturated Groups | TRANSITIONS OPTICAL, LTD. (IE) | 2024-11-14 | — | — | US | disclosed |
| EP-3621958-B9 | PHOTOCHROMIC INDENO FUSED PHENANTHRENOPYRAN COMPOUNDS | TRANSITIONS OPTICAL LTD (IE) | 2024-09-25 | — | — | EP | disclosed |
| EP-3621958-B1 | PHOTOCHROMIC INDENO FUSED PHENANTHRENOPYRAN COMPOUNDS | TRANSITIONS OPTICAL LTD (IE) | 2024-07-10 | — | — | EP | disclosed |
| EP-4313996-A1 | INDENONAPHTHOPYRANS HAVING TRIALKYLSILYL AND ETHYLENICALLY UNSATURATED GROUPS | Transitions Optical, Ltd. (IE) | 2024-02-07 | — | — | EP | disclosed |
| US-11874434-B2 | Ophthalmic devices comprising photochromic materials with reactive substituents | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2024-01-16 | — | — | US | disclosed |
| CN-117043168-A | Indenonaphthopyrans having trialkylsilyl groups and ethylenically unsaturated groups | 光学转变有限公司 | 2023-11-10 | — | — | CN | disclosed |
| EP-3898636-B9 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-11-08 | — | — | EP | disclosed |
| CN-110730778-B | Photochromic indeno-fused phenanthropyran compounds | 光学转变有限公司 | 2023-09-12 | — | — | CN | disclosed |
| EP-3898636-B1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-08-30 | — | — | EP | disclosed |
| WO-2001019813-A1 | NOVEL INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2001-03-22 | — | — | WO | disclosed |
| EP-1036077-A1 | PHOTOCHROMIC PYRANO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2000-09-20 | — | — | EP | disclosed |
| US-6106744-A | HAVING A SUBSTITUTED OR UNSUBSTITUTED ?S? PYRAN RING, THE 3,4 POSITIONS OF WHICH ARE FUSED TO THE F SIDE OF THE NAPHTHO PORTION OF THE NAPHTHOPYRAN, AND CERTAIN SUBSTITUENTS AT THE 2-POSITION OF THE ?T? PYRAN RING. | PPG INDUSTRIES OHIO, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-1000025-A1 | SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2000-05-17 | — | — | EP | disclosed |
| US-6022495-A | FOR OPTICAL APPLICATIONS | TRANSITIONS OPTICAL, INC. (US) | 2000-02-08 | — | — | US | disclosed |
| WO-2000002884-A2 | PHOTOCHROMIC BENZOPYRANO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2000-01-20 | — | — | WO | disclosed |
| WO-1999031081-A1 | PH SENSITIVE PHOTOCHROMIC DYES | JAMES ROBINSON LIMITED (GB) | 1999-06-24 | — | — | WO | disclosed |
| WO-1999028323-A1 | NOVEL PHOTOCHROMIC PYRANO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 1999-06-10 | — | — | WO | disclosed |
| WO-1998055457-A1 | SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 1998-12-10 | — | — | WO | disclosed |
| US-5658500-A | REVERSIBLE PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 1997-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240376132-A1 | Indenonaphthopyrans Having Trialkylsilyl and Ethylenically Unsaturated Groups | B3GNT2, ERLIN1, RPN1 | LMNA 1851/4885PKM 3022/4885TSHR 3338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.