Sugi Predict

Sugi Predict / Compounds / SCHEMBL3143230

SCHEMBL3143230

SCHEMBL3143230

C#CC(O)(c1ccccc1)c1ccc(N2CCCCC2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 6/20 0.46
▸ MAPT P10636 6/20 0.46
▸ NPC1 O15118 5/20 0.46
▸ SMN1; SMN2 Q16637 5/20 0.46
▸ TP53 P04637 3/20 0.46
▸ PKM P14618 1/20 0.46
▸ NFKB1 P19838 1/20 0.46
▸ NFKB2 Q00653 1/20 0.46
▸ RELA Q04206 1/20 0.46
▸ LMNA P02545 4/20 0.45
▸ L3MBTL1 Q9Y468 4/20 0.45
▸ ALDH1A1 P00352 3/20 0.45
▸ ALOX15 P16050 3/20 0.45
▸ HSD17B10 Q99714 2/20 0.45
▸ HPGD P15428 2/20 0.45
▸ TSHR P16473 1/20 0.45
▸ STAT1 P42224 1/20 0.45
▸ KMT2A Q03164 3/20 0.44
▸ NPY2R P49146 2/20 0.43
▸ MEN1 O00255 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21940997 1.00 RAB9A (0.46) RAB9AMAPTNPC1SMN1; SMN2TP53
SCHEMBL1793404 0.98 MAPT (0.46) RAB9AMAPTNPC1SMN1; SMN2TP53
SCHEMBL7477981 0.94 ALDH1A1 (0.44) RAB9AMAPTNPC1SMN1; SMN2TP53
SCHEMBL8512751 0.92 HDAC6 (0.43) RAB9AMAPTNPC1SMN1; SMN2TP53
SCHEMBL1958061 0.86 NPC1 (0.53) RAB9AMAPTNPC1SMN1; SMN2TP53
SCHEMBL162513 0.86 LMNA (0.51) RAB9AMAPTNPC1SMN1; SMN2TP53
SCHEMBL28370082 0.86 LMNA (0.51) RAB9AMAPTNPC1SMN1; SMN2TP53
SCHEMBL25954126 0.85 TERT (0.41) RAB9AMAPTNPC1SMN1; SMN2TP53
SCHEMBL1045601 0.85 HTR3E (0.54) MAPTALDH1A1HSD17B10TSHRCHRM2
SCHEMBL26937823 0.85 MAPT (0.39) RAB9AMAPTNPC1SMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11485812-B2 Pyranoquinazoline derivatives and naphthopyran derivatives KANTO KAGAKU KABUSHIKI KAISHA (JP) 2022-11-01 — — US disclosed
US-20200131193-A1 PYRANOQUINAZOLINE DERIVATIVES AND NAPHTHOPYRAN DERIVATIVES KANTO KAGAKU KABUSHIKI KAISHA (JP) 2020-04-30 — — US disclosed
US-20200131193-A1 PYRANOQUINAZOLINE DERIVATIVES AND NAPHTHOPYRAN DERIVATIVES KANTO KAGAKU KABUSHIKI KAISHA (JP) 2020-04-30 — — US disclosed
CN-110896637-A Pyrano quinazoline derivatives and naphthopyran derivatives 关东化学株式会社 2020-03-20 — — CN disclosed
CN-106854194-B Photosensitive material and optical device 财团法人工业技术研究院 2019-12-06 — — CN disclosed
US-9771518-B2 Photo responsive material and optical device INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2017-09-26 — — US disclosed
US-9771518-B2 Photo responsive material and optical device INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2017-09-26 — — US disclosed
US-9771518-B2 Photo responsive material and optical device INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2017-09-26 — — US disclosed
US-20170166814-A1 PHOTO RESPONSIVE MATERIAL AND OPTICAL DEVICE INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2017-06-15 — — US disclosed
US-20170166814-A1 PHOTO RESPONSIVE MATERIAL AND OPTICAL DEVICE INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2017-06-15 — — US disclosed
US-20070138449-A1 Photochromic materials having electron-withdrawing substituents TRANSITIONS OPTICAL LIMITED (IE) 2007-06-21 — — US disclosed
EP-0973761-B1 RED COLOURING HYPERCHROMIC 3H-NAPHTHO 2,1-b ]PYRANS JAMES ROBINSON LTD (GB) 2002-07-03 — — EP disclosed
EP-1117656-B1 GREY COLOURING PHOTOCHROMIC FUSED PYRANS JAMES ROBINSON LTD (GB) 2002-05-29 — — EP disclosed
US-6387512-B1 FOR COLORING INKS, FUELS, PLASTICS OR GLASS JAMES ROBINSON LIMITED (GB) 2002-05-14 — — US disclosed
EP-1140892-A1 PHOTOCHROMIC SUBSTIITUTED 2H-NAPHTHO[1,2-B]PYRANS JAMES ROBINSON LIMITED (GB) 2001-10-10 — — EP disclosed
US-6294112-B1 Red coloring hyperchromic 3H-naphtho[2,1-B]pyrans JAMES ROBINSON LIMITED (GB) 2001-09-25 — — US disclosed
EP-1117656-A1 GREY COLOURING PHOTOCHROMIC FUSED PYRANS JAMES ROBINSON LIMITED (GB) 2001-07-25 — — EP disclosed
WO-2001012619-A1 RAPID FADING PHOTO-RESPONSIVE MATERIALS JAMES ROBINSON LIMITED (GB) 2001-02-22 — — WO disclosed
WO-2000035902-A1 PHOTOCHROMIC SUBSTITUTED 2H-NAPHTHO[1,2-b]PYRANS JAMES ROBINSON LIMITED (GB) 2000-06-22 — — WO disclosed
WO-2000018755-A1 GREY COLOURING PHOTOCHROMIC FUSED PYRANS JAMES ROBINSON LIMITED (GB) 2000-04-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11485812-B2 Pyranoquinazoline derivatives and naphthopyran derivatives PPOX, TYR, NQO1 RAB9A 1978/4885MAPT 3170/4885NPC1 4371/4885
US-20170166814-A1 PHOTO RESPONSIVE MATERIAL AND OPTICAL DEVICE LSM12, MYB, CRY1 RAB9A 2342/4885MAPT 1230/4885NPC1 3343/4885
US-20200131193-A1 PYRANOQUINAZOLINE DERIVATIVES AND NAPHTHOPYRAN DERIVATIVES PPOX, TYR, NQO1 RAB9A 1693/4885MAPT 3331/4885NPC1 4373/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.