Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21940997 | 0.98 | RAB9A (0.46) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL3143230 | 0.98 | RAB9A (0.46) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL8512751 | 0.93 | HDAC6 (0.43) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL7477981 | 0.92 | ALDH1A1 (0.44) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL162513 | 0.88 | LMNA (0.51) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL28370082 | 0.88 | LMNA (0.51) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL1045601 | 0.86 | HTR3E (0.54) | MAPTALDH1A1TSHRHSD17B10CHRM4 | |
| SCHEMBL26937823 | 0.86 | MAPT (0.39) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL2236214 | 0.85 | KCNA3 (0.40) | L3MBTL1NPY2RCHRM4CHRM3GCK | |
| SCHEMBL1958061 | 0.84 | NPC1 (0.53) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3367143-B1 | POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | TRANSITIONS OPTICAL INC (US) | 2023-01-11 | — | — | EP | disclosed |
| EP-1639058-B1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2020-10-21 | — | — | EP | disclosed |
| CN-105838349-B | photochromic compounds | 光学转变公司 | 2019-12-06 | — | — | CN | disclosed |
| EP-2357217-B9 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2019-03-13 | — | — | EP | disclosed |
| EP-2357217-B1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2018-10-31 | — | — | EP | disclosed |
| EP-2360224-B1 | Photochromic compounds | TRANSITIONS OPTICAL INC (US) | 2018-10-17 | — | — | EP | disclosed |
| EP-3367143-A1 | POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | Transitions Optical, Inc. (US) | 2018-08-29 | — | — | EP | disclosed |
| EP-1642160-B1 | POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | TRANSITIONS OPTICAL INC (US) | 2018-04-11 | — | — | EP | disclosed |
| US-9200203-B2 | Phototropic liquid crystal material and processes | ALPHAMICRON INCORPORATED (US) | 2015-12-01 | — | — | US | disclosed |
| US-9102652-B2 | Dichroic-photochromic 2H-naphtho[1,2-b]pyran compounds and devices | ALPHAMICRON INCORPORATED (US) | 2015-08-11 | — | — | US | disclosed |
| WO-2005005570-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2005-01-20 | — | — | WO | disclosed |
| WO-2005006035-A1 | POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | TRANSITIONS OPTICAL, INC. (US) | 2005-01-20 | — | — | WO | disclosed |
| US-20050004361-A1 | Thermally reversible; absorption ratio greater than 2.3 | TRANSITIONS OPTICAL LIMITED (IE) | 2005-01-06 | — | — | US | disclosed |
| EP-0973761-B1 | RED COLOURING HYPERCHROMIC 3H-NAPHTHO 2,1-b ]PYRANS | JAMES ROBINSON LTD (GB) | 2002-07-03 | — | — | EP | disclosed |
| EP-1117656-B1 | GREY COLOURING PHOTOCHROMIC FUSED PYRANS | JAMES ROBINSON LTD (GB) | 2002-05-29 | — | — | EP | disclosed |
| US-6387512-B1 | FOR COLORING INKS, FUELS, PLASTICS OR GLASS | JAMES ROBINSON LIMITED (GB) | 2002-05-14 | — | — | US | disclosed |
| US-6294112-B1 | Red coloring hyperchromic 3H-naphtho[2,1-B]pyrans | JAMES ROBINSON LIMITED (GB) | 2001-09-25 | — | — | US | disclosed |
| EP-1117656-A1 | GREY COLOURING PHOTOCHROMIC FUSED PYRANS | JAMES ROBINSON LIMITED (GB) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018755-A1 | GREY COLOURING PHOTOCHROMIC FUSED PYRANS | JAMES ROBINSON LIMITED (GB) | 2000-04-06 | — | — | WO | disclosed |
| WO-1999031081-A1 | PH SENSITIVE PHOTOCHROMIC DYES | JAMES ROBINSON LIMITED (GB) | 1999-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004361-A1 | Thermally reversible; absorption ratio greater than 2.3 | CCND1, CCND3, CCND2 | MAPT 4150/4885SMN1; SMN2 1502/4885NPC1 4806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.