Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.49 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | EGFR | P00533 | 7/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16257575 | 0.87 | MAPT (0.48) | ANO1ANO2ABCG2KDREGFR | |
| SCHEMBL16257589 | 0.81 | CSNK2A2 (0.48) | EGFRIGF1R | |
| SCHEMBL16257609 | 0.78 | CSF1R (0.47) | KDREGFRTNIK | |
| SCHEMBL16257563 | 0.78 | ALDH1A1 (0.38) | ABCG2KDREGFRAURKBAURKA | |
| SCHEMBL16257513 | 0.76 | CSF1R (0.45) | KDREGFRTNIK | |
| SCHEMBL16257514 | 0.71 | KDM4E (0.46) | ABCG2EGFR | |
| SCHEMBL16737111 | 0.70 | ANO1 (0.56) | ANO1ANO2TNIKALOX15 | |
| SCHEMBL15033668 | 0.69 | KMO (0.58) | KDREGFR | |
| SCHEMBL16257511 | 0.69 | DHODH (0.55) | KDREGFRBRAF | |
| SCHEMBL6055173 | 0.69 | ATM (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |