Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16264765 | 0.85 | PDGFRB (0.44) | NPC1MAPTRAB9AALDH1A1PDGFRB | |
| SCHEMBL19387101 | 0.83 | DRD2 (0.43) | NPC1MAPTRAB9AALDH1A1PDGFRB | |
| SCHEMBL18625959 | 0.82 | NAMPT (0.43) | NPC1MAPTRAB9AALDH1A1PDGFRB | |
| SCHEMBL18625982 | 0.79 | NPC1 (0.40) | NPC1MAPTRAB9AALDH1A1PDGFRB | |
| SCHEMBL12251051 | 0.77 | CYP19A1 (0.60) | NPC1RAB9AKDRMEN1KMT2A | |
| SCHEMBL16263153 | 0.75 | CYP19A1 (0.57) | NPC1RAB9AKDRMEN1KMT2A | |
| SCHEMBL16263155 | 0.73 | CCNE1 (0.37) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL29009129 | 0.73 | CA12 (0.46) | NPC1MAPTRAB9AALDH1A1PDGFRB | |
| SCHEMBL30434942 | 0.73 | CA12 (0.46) | NPC1MAPTRAB9AALDH1A1PDGFRB | |
| SCHEMBL12251050 | 0.71 | TEK (0.55) | NPC1RAB9AALDH1A1KDRGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771389-B2 | Tylosin derivatives and method for preparation thereof | THE KITASAKO INSTITUTE (JP) | 2017-09-26 | — | — | US | disclosed |
| US-9771389-B2 | Tylosin derivatives and method for preparation thereof | THE KITASAKO INSTITUTE (JP) | 2017-09-26 | — | — | US | disclosed |
| US-9593140-B2 | Antibacterial tylosin derivatives and methods for their preparation | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-03-14 | — | — | US | disclosed |
| US-9593140-B2 | Antibacterial tylosin derivatives and methods for their preparation | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-03-14 | — | — | US | disclosed |
| US-20160108077-A1 | TYLOSIN DERIVATIVES AND METHOD FOR PREPARATION THEREOF | THE KITASAKO INSTITUTE (JP) | 2016-04-21 | — | — | US | disclosed |
| US-20140349954-A1 | ANTIBACTERIAL TYLOSIN DERIVATIVES AND METHODS FOR THEIR PREPARATION | ELANCO ANIMAL HEALTH GMBH (DE) | 2014-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160108077-A1 | TYLOSIN DERIVATIVES AND METHOD FOR PREPARATION THEREOF | TMSB10, MLN, TMSB4X | NPC1 196/4885MAPT 3249/4885RAB9A 3663/4885 |
| US-20140349954-A1 | ANTIBACTERIAL TYLOSIN DERIVATIVES AND METHODS FOR THEIR PREPARATION | MLN, TMSB10, TMSB4X | NPC1 428/4885MAPT 2502/4885RAB9A 2852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.