Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494912 | 0.83 | CFTR (0.40) | MEN1NPC1MAPTHTTRAB9A | |
| SCHEMBL16337904 | 0.79 | MEN1 (0.51) | L3MBTL1HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL16263912 | 0.77 | BCL3 (0.42) | HDAC6MEN1NPC1MAPTHTT | |
| SCHEMBL16263844 | 0.76 | KDM1A (0.36) | MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL16263849 | 0.76 | CNR2 (0.42) | MEN1NPC1MAPTHTTRAB9A | |
| SCHEMBL19494633 | 0.76 | ALDH1A1 (0.33) | MEN1NPC1POLBMAPTRAB9A | |
| SCHEMBL16263934 | 0.74 | MAPT (0.33) | HDAC6MEN1MAPTHTTKMT2A | |
| SCHEMBL16261720 | 0.72 | RAB9A (0.47) | L3MBTL1MEN1NPC1GAAMAPT | |
| SCHEMBL16338289 | 0.71 | CFTR (0.59) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL16246344 | 0.70 | CFTR (0.60) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014180562-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2014-11-13 | — | — | WO | disclosed |