Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3743731 | 0.84 | AKR1B1 (0.59) | SMN1; SMN2ALDH1A1HPGDAKR1B1MAPK1 | |
| SCHEMBL28152937 | 0.83 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1HPGDTSHRGAA | |
| SCHEMBL19289915 | 0.83 | AKR1B1 (0.46) | SMN1; SMN2ALDH1A1HPGDSLC22A12AKR1B1 | |
| SCHEMBL31446049 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1HPGDTSHRGAA | |
| SCHEMBL11875050 | 0.81 | AKR1B1 (0.67) | SMN1; SMN2ALDH1A1HPGDSLC22A12AKR1B1 | |
| SCHEMBL14660828 | 0.79 | XDH (0.47) | SMN1; SMN2ALDH1A1HPGDTSHRGAA | |
| SCHEMBL14661541 | 0.79 | P2RX7 (0.44) | SMN1; SMN2ALDH1A1HPGDTSHRGAA | |
| SCHEMBL17681684 | 0.78 | PDE4D (0.40) | SMN1; SMN2ALDH1A1HPGDTSHRGAA | |
| SCHEMBL2373994 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1HPGDTSHRAKR1B1 | |
| SCHEMBL28158406 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1HPGDAKR1B1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3004061-B1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | LILLY CO ELI (US) | 2017-08-30 | — | — | EP | disclosed |
| EP-3004061-A1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | ELI LILLY AND CO. (US) | 2016-04-13 | — | — | EP | disclosed |
| US-8962654-B2 | 3,4-dihydroisoquinolin-2(1H)-yl compounds | ELI LILLY AND COMPANY (US) | 2015-02-24 | — | — | US | disclosed |
| US-20140357664-A1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2014-12-04 | — | — | US | disclosed |
| WO-2014193781-A1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2014-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357664-A1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | PARK7, SNCA, COMT | SMN1; SMN2 1340/4885ALDH1A1 1468/4885HPGD 917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.