Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | LDHA | P00338 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16273551 | 0.96 | NPC1 (0.48) | NPC1RAB9AMAPTGLO1EGFR | |
| SCHEMBL21477023 | 0.86 | MAPT (0.59) | NPC1RAB9AMAPTGLO1LDHA | |
| SCHEMBL16273550 | 0.79 | RAB9A (0.53) | NPC1RAB9AMAPTEGFRLDHA | |
| SCHEMBL21477026 | 0.79 | RAB9A (0.53) | NPC1RAB9AMAPTLDHAALDH1A1 | |
| SCHEMBL16273525 | 0.78 | MAPT (0.46) | NPC1RAB9AMAPTEGFRLDHA | |
| SCHEMBL16273552 | 0.74 | MAPT (0.51) | RAB9AMAPTLDHAALDH1A1L3MBTL1 | |
| SCHEMBL12568360 | 0.72 | RAB9A (0.57) | NPC1RAB9AMAPTEGFRLDHA | |
| SCHEMBL446619 | 0.72 | NPC1 (1.00) | NPC1GLO1MAP3K11ALOX15DYRK3 | |
| SCHEMBL30587350 | 0.72 | NPC1 (1.00) | NPC1GLO1MAP3K11ALOX15DYRK3 | |
| SCHEMBL16273503 | 0.71 | RAB9A (0.50) | NPC1RAB9AMAPTLDHAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3799871-A2 | PYRAZOL-3-ONES THAT ACTIVATE PRO-APOTOTIC BAX | Dana Farber Cancer Institute, Inc. (US) | 2021-04-07 | — | — | EP | disclosed |
| US-9303024-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-20140357687-A1 | Pyrazol-3-ones That Activate Pro-apoptotic BAX | DANA FARBER CANCER INSTITUTE, INC. (US) | 2014-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357687-A1 | Pyrazol-3-ones That Activate Pro-apoptotic BAX | BAX, BAD, CASP3 | NPC1 2657/4885RAB9A 1557/4885MAPT 3506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.