Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | RARA | P10276 | 2/20 | 0.47 |
| ▸ | RARB | P10826 | 2/20 | 0.47 |
| ▸ | RARG | P13631 | 2/20 | 0.47 |
| ▸ | RXRA | P19793 | 2/20 | 0.47 |
| ▸ | LDHA | P00338 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21477026 | 0.82 | RAB9A (0.53) | MAPTRAB9ACYP2C9LDHAMEN1 | |
| SCHEMBL16273550 | 0.82 | RAB9A (0.53) | MAPTRAB9AALOX5LDHAMEN1 | |
| SCHEMBL12568360 | 0.77 | RAB9A (0.57) | MAPTRAB9ACYP2C9LDHAMAPK1 | |
| SCHEMBL8421185 | 0.76 | PTGS2 (0.80) | PTGS2ALOX5CYP2C9RARARARB | |
| SCHEMBL8420828 | 0.76 | PTGS2 (0.80) | PTGS2ALOX5CYP2C9RARARARB | |
| SCHEMBL1548505 | 0.74 | LDHA (0.75) | CYP2C9LDHAKDM4EALDH1A1POLB | |
| SCHEMBL16273545 | 0.74 | NPC1 (0.52) | MAPTRAB9ALDHAMEN1LMNA | |
| SCHEMBL16273551 | 0.74 | NPC1 (0.48) | MAPTRAB9ALDHAMAPK1KDM4E | |
| SCHEMBL6164498 | 0.73 | — | — | |
| SCHEMBL25328164 | 0.73 | RAB9A (0.58) | MAPTRAB9ACYP2C9LDHAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358960-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-06-14 | — | — | US | disclosed |
| US-20210032234-A1 | PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX | DANA-FARBER CANCER INSTITUTE, INC. | 2021-02-04 | — | — | US | disclosed |
| EP-2766355-B1 | PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX | DANA FARBER CANCER INST INC (US) | 2020-12-23 | — | — | EP | disclosed |
| US-10844053-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-11-24 | — | — | US | disclosed |
| US-9303024-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-20140357687-A1 | Pyrazol-3-ones That Activate Pro-apoptotic BAX | DANA FARBER CANCER INSTITUTE, INC. (US) | 2014-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210032234-A1 | PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX | BAX, BAD, CASP3 | MAPT 3506/4885RAB9A 1557/4885PTGS2 1319/4885 |
| US-10844053-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | BAX, BAD, CASP3 | MAPT 3506/4885RAB9A 1557/4885PTGS2 1319/4885 |
| US-20140357687-A1 | Pyrazol-3-ones That Activate Pro-apoptotic BAX | BAX, BAD, CASP3 | MAPT 3506/4885RAB9A 1557/4885PTGS2 1319/4885 |
| US-11358960-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | BAX, BAD, CASP3 | MAPT 3506/4885RAB9A 1557/4885PTGS2 1319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.