Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | AR | P10275 | 5/20 | 0.52 |
| ▸ | LDHA | P00338 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16273550 | 0.87 | RAB9A (0.53) | RAB9AMAPTARLDHAKDM4E | |
| SCHEMBL16273552 | 0.82 | MAPT (0.51) | RAB9AMAPTLDHAKDM4EMEN1 | |
| SCHEMBL12568360 | 0.80 | RAB9A (0.57) | RAB9AMAPTLDHAKDM4EL3MBTL1 | |
| SCHEMBL16273545 | 0.79 | NPC1 (0.52) | RAB9AMAPTARLDHAKDM4E | |
| SCHEMBL21477021 | 0.79 | LDHA (0.51) | RAB9AMAPTARLDHAKDM4E | |
| SCHEMBL16273551 | 0.78 | NPC1 (0.48) | RAB9AMAPTARLDHAKDM4E | |
| SCHEMBL1548505 | 0.76 | LDHA (0.75) | LDHAKDM4EL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL25329191 | 0.76 | RAB9A (0.59) | RAB9AMAPTARLDHAKDM4E | |
| SCHEMBL16273503 | 0.76 | RAB9A (0.50) | RAB9AMAPTARLDHAKDM4E | |
| SCHEMBL25328164 | 0.75 | RAB9A (0.58) | RAB9AMAPTARLDHAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844053-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-11-24 | — | — | US | disclosed |
| US-20190315730-A1 | PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX | DANA-FARBER CANCER INSTITUTE, INC. | 2019-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10844053-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | BAX, BAD, CASP3 | RAB9A 1557/4885MAPT 3506/4885AR 3793/4885 |
| US-20190315730-A1 | PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX | BAX, BAD, CASP3 | RAB9A 1557/4885MAPT 3506/4885AR 3793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.