Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1478009 | 0.85 | HDAC1 (0.61) | ALDH1A1TDP1HDAC2HDAC8HDAC6 | |
| SCHEMBL7441543 | 0.84 | ALDH1A1 (0.67) | ALDH1A1KEAP1FFAR1TDP1HDAC2 | |
| SCHEMBL10530175 | 0.84 | ALDH1A1 (0.67) | ALDH1A1KEAP1FFAR1TDP1HDAC2 | |
| SCHEMBL6164475 | 0.83 | MAPT (0.61) | ALDH1A1HDAC2HDAC8HDAC6HDAC1 | |
| SCHEMBL9765869 | 0.83 | ALDH1A1 (0.64) | ALDH1A1KEAP1FFAR1TDP1HDAC2 | |
| SCHEMBL8123200 | 0.81 | MAPT (0.64) | ALDH1A1HDAC2HDAC8HDAC6HDAC1 | |
| SCHEMBL7864099 | 0.81 | MAPT (0.64) | ALDH1A1HDAC2HDAC8HDAC6HDAC1 | |
| SCHEMBL8108303 | 0.81 | MAPT (0.64) | ALDH1A1HDAC2HDAC8HDAC6HDAC1 | |
| SCHEMBL2163306 | 0.80 | ALDH1A1 (0.61) | ALDH1A1KEAP1FFAR1TDP1HDAC2 | |
| SCHEMBL9876476 | 0.80 | ALDH1A1 (0.61) | ALDH1A1KEAP1FFAR1TDP1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 840 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116278060-A | Epoxy vinyl glass fiber reinforced plastic wedge-shaped strip, preparation method and preparation system thereof | 北京玻钢院复合材料有限公司 | 2023-06-23 | — | — | CN | claimed |
| EP-3493814-A1 | LIPID-SUBSTITUTED AMINO 1,2-AND 1,3-DIOL COMPOUNDS AS MODULATORS OF TLR2 DIMERIZATION | Neuropore Therapies, Inc. (US) | 2019-06-12 | — | — | EP | claimed |
| CN-109574972-A | A kind of 3- alkyl substitution -4- chromanone compound and preparation method thereof | 郑州大学 | 2019-04-05 | — | — | CN | claimed |
| US-10221146-B2 | Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease | LYCERA CORPORATION (US) | 2019-03-05 | — | — | US | claimed |
| WO-2018026866-A1 | LIPID-SUBSTITUTED AMINO 1,2-AND 1,3-DIOL COMPOUNDS AS MODULATORS OF TLR2 DIMERIZATION | NEUROPORE THERAPIES, INC. (US) | 2018-02-08 | — | — | WO | claimed |
| US-20180030005-A1 | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | MERCK SHARP & DOHME LLC | 2018-02-01 | — | — | US | claimed |
| CN-105585511-B | (R) preparation method of N tertbutyloxycarbonyls biphenyl Propanolamine | 浙江大学 | 2017-05-31 | — | — | CN | claimed |
| CN-105585511-A | Preparation method of (R)-N-t-butyloxycarboryl biphenyl alaninol | UNIV ZHEJIANG | 2016-05-18 | — | — | CN | claimed |
| CN-105367611-A | Olefin high-temperature polymerization metallocene catalyst and preparation method thereof and application of olefin high-temperature polymerization metallocene catalyst in olefin polymerization | UNIV EAST CHINA SCIENCE & TECH | 2016-03-02 | — | — | CN | claimed |
| CN-104024232-A | NOVEL PYRAZINE DERIVATIVES | HOFFMANN LA ROCHE | 2014-09-03 | — | — | CN | claimed |
| EP-1125929-A1 | Method for making (-)-(2R,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-methoxycarbonylamino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester | Pfizer Products Inc. (US) | 2001-08-22 | — | — | EP | claimed |
| EP-1021424-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-26 | — | — | EP | claimed |
| US-5830869-A | METALLOPROTEASE INHIBITOR | PHARMACIA & UPJOHN COMPANY | 1998-11-03 | — | — | US | claimed |
| WO-1997048688-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-24 | — | — | WO | claimed |
| EP-0586418-A1 | SUBSTITUTED TRIAZOLINONES | BAYER AG (DE) | 1994-03-16 | — | — | EP | claimed |
| US-5276008-A | Herbicides and plant growth regulators | BAYER AKTIENGESELLSCHAFT (DE) | 1994-01-04 | — | — | US | claimed |
| WO-1992020663-A1 | SUBSTITUTED TRIAZOLINONES | BAYER AKTIENGESELLSCHAFT (DE) | 1992-11-26 | — | — | WO | claimed |
| EP-0502307-A2 | Substituted 4,5-diamino-1,2,4-triazol-3-(thi)ones | BAYER AG (DE) | 1992-09-09 | — | — | EP | claimed |
| EP-0002792-A1 | 3-Aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them | SANDOZ AG (CH) | 1979-07-11 | — | — | EP | claimed |
| US-4101579-A | Phenethanolamine ethers | ALLEN & HANBURYS LIMITED (GB) | 1978-07-18 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180030005-A1 | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | RORB, RORA, RORC | ALDH1A1 696/4885KEAP1 2776/4885FFAR1 1789/4885 |
| US-10221146-B2 | Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease | RORB, RORA, RORC | ALDH1A1 722/4885KEAP1 2796/4885FFAR1 1877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.