Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 8/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15196662 | 0.86 | DHODH (0.62) | DHODHMAPTTP53THRBGAA | |
| Laflunimus SCHEMBL9234178 | 0.82 | DHODH (0.67) | DHODHMAPTTP53THRBGAA | |
| Laflunimus SCHEMBL21132 | 0.82 | DHODH (0.67) | DHODHMAPTTP53THRBGAA | |
| Laflunimus SCHEMBL29677348 | 0.82 | DHODH (0.67) | DHODHMAPTTP53THRBGAA | |
| Laflunimus SCHEMBL22908 | 0.82 | DHODH (0.67) | DHODHMAPTTP53THRBGAA | |
| SCHEMBL18118641 | 0.79 | DHODH (0.70) | DHODHMAPTTP53ALDH1A1HTT | |
| SCHEMBL27242987 | 0.76 | DHODH (0.74) | DHODHTP53ALDH1A1HTTMEN1 | |
| SCHEMBL25813258 | 0.76 | DHODH (0.74) | DHODHTP53ALDH1A1HTTMEN1 | |
| SCHEMBL9017556 | 0.75 | DHODH (0.49) | DHODHMAPTTP53NPSR1MEN1 | |
| SCHEMBL16741993 | 0.74 | DHODH (0.70) | DHODHMAPTALDH1A1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9468615-B2 | Use of malononitrilamides in neuropathic pain | ALGIAX PHARMACEUTICALS GMBH (DE) | 2016-10-18 | — | — | US | disclosed |
| US-20140357722-A1 | Use of Malononitrilamides in Neuropathic Pain | ALGIAX PHARMACEUTICALS GMBH (DE) | 2014-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357722-A1 | Use of Malononitrilamides in Neuropathic Pain | PMP22, GAP43, ACHE | DHODH 896/4885MAPT 64/4885TP53 4623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.