SCHEMBL1628510

SCHEMBL1628510

Fc1cc(-c2ccc3cc(CCC4CCCC4)ccc3c2)cc(F)c1F

nearest known ligand 0.45

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 10/20 0.45
BCHE P06276 1/20 0.39
AAK1 Q2M2I8 1/20 0.36
ESR1 P03372 1/20 0.36
ESR2 Q92731 1/20 0.36
PDGFRB P09619 1/20 0.34
PDGFRA P16234 1/20 0.34
FFAR4 Q5NUL3 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3160386 0.88 HRH3 (0.43) HRH3BCHEESR1ESR2
SCHEMBL3153646 0.88 HRH3 (0.43) HRH3BCHEESR1ESR2
SCHEMBL3153639 0.88 HRH3 (0.43) HRH3BCHEESR1ESR2
SCHEMBL3160378 0.88 HRH3 (0.43) HRH3BCHEESR1ESR2
SCHEMBL3165477 0.86 HRH3 (0.41) HRH3BCHEESR2
SCHEMBL3165490 0.86 HRH3 (0.41) HRH3BCHEESR2
SCHEMBL19720332 0.85 GPR84 (0.39) HRH3AAK1PDGFRBPDGFRA
SCHEMBL3163927 0.85 HRH3 (0.41) HRH3BCHE
SCHEMBL3163917 0.85 HRH3 (0.41) HRH3BCHE
SCHEMBL8767230 0.82 GPR84 (0.39) HRH3AAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210122978-A1 Liquid Crystals Comprising Cyclopentane Groups VVI BRIGHT CHINA LTD (CN) 2021-04-29 US disclosed
US-20210122978-A1 Liquid Crystals Comprising Cyclopentane Groups VVI BRIGHT CHINA LTD (CN) 2021-04-29 US disclosed
US-10745617-B2 Liquid crystals comprising cyclopentane groups VVI BRIGHT CHINA LTD (CN) 2020-08-18 US disclosed
US-10745617-B2 Liquid crystals comprising cyclopentane groups VVI BRIGHT CHINA LTD (CN) 2020-08-18 US disclosed
US-20180163131-A1 LIQUID CRYSTALS COMPRISING CYCLOPENTANE GROUPS VVI BRIGHT, INC. 2018-06-14 US disclosed
US-20180163131-A1 LIQUID CRYSTALS COMPRISING CYCLOPENTANE GROUPS VVI BRIGHT, INC. 2018-06-14 US disclosed
US-20180163131-A1 LIQUID CRYSTALS COMPRISING CYCLOPENTANE GROUPS VVI BRIGHT, INC. 2018-06-14 US disclosed
US-9822303-B2 Liquid crystals comprising cyclopentane groups VVI BRIGHT CHINA LTD (CN) 2017-11-21 US disclosed
US-9822303-B2 Liquid crystals comprising cyclopentane groups VVI BRIGHT CHINA LTD (CN) 2017-11-21 US disclosed
US-9822303-B2 Liquid crystals comprising cyclopentane groups VVI BRIGHT CHINA LTD (CN) 2017-11-21 US disclosed
US-8801966-B2 Liquid crystals comprising cyclopentane groups VVI BRIGHT CHINA LTD. (CN) 2014-08-12 US disclosed
US-8801966-B2 Liquid crystals comprising cyclopentane groups VVI BRIGHT CHINA LTD. (CN) 2014-08-12 US disclosed
CN-101978024-B Liquid crystals comprising cyclopentane groups JINGMEISHENG OPTOELECTRIC MATERIAL NANJING CO LTD 2014-05-07 CN disclosed
CN-103320141-A Liquid crystals comprising cyclopentane groups VVI BRIGHT INC 2013-09-25 CN disclosed
CN-103319306-A Liquid crystals comprising cyclopentane groups VVI BRIGHT INC 2013-09-25 CN disclosed
US-20110089374-A1 Liquid Crystals Comprising Cyclopentane Groups VVI BRIGHT, INC. (US) 2011-04-21 US disclosed
US-20110089374-A1 Liquid Crystals Comprising Cyclopentane Groups VVI BRIGHT, INC. (US) 2011-04-21 US disclosed
US-20110089374-A1 Liquid Crystals Comprising Cyclopentane Groups VVI BRIGHT, INC. (US) 2011-04-21 US disclosed
WO-2009100204-A1 LIQUID CRYSTALS COMPRISING CYCLOPENTANE GROUPS VVI BRIGHT, INC. (US) 2009-08-13 WO disclosed
WO-2009100204-A1 LIQUID CRYSTALS COMPRISING CYCLOPENTANE GROUPS VVI BRIGHT, INC. (US) 2009-08-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210122978-A1 Liquid Crystals Comprising Cyclopentane Groups CXCR5, CCL5, ELOC HRH3 4754/4885BCHE 3121/4885AAK1 3370/4885
US-10745617-B2 Liquid crystals comprising cyclopentane groups CXCR5, CCL5, ELOC HRH3 4754/4885BCHE 3121/4885AAK1 3370/4885
US-20180163131-A1 LIQUID CRYSTALS COMPRISING CYCLOPENTANE GROUPS CXCR5, CCL5, ELOC HRH3 4754/4885BCHE 3121/4885AAK1 3370/4885
US-20110089374-A1 Liquid Crystals Comprising Cyclopentane Groups CXCR5, CCL5, ELOC HRH3 4754/4885BCHE 3121/4885AAK1 3370/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.