Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5906335 | 0.77 | ALDH1A1 (0.40) | MGLLNPBWR1MCHR1HCAR1POLB | |
| SCHEMBL19643648 | 0.76 | P2RX7 (0.32) | ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL16283450 | 0.76 | SMN1; SMN2 (0.43) | NPBWR1MCHR1KDM4EHPGDALDH1A1 | |
| SCHEMBL8721136 | 0.72 | L3MBTL1 (0.51) | NPBWR1MCHR1POLBALDH1A1NPC1 | |
| SCHEMBL8721252 | 0.69 | PTGS1 (0.40) | NPBWR1MCHR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8775840 | 0.68 | NPC1 (0.54) | MGLLNPBWR1MCHR1POLBALDH1A1 | |
| SCHEMBL8718771 | 0.67 | MMP13 (0.36) | NPBWR1MCHR1POLBKDM4EALDH1A1 | |
| SCHEMBL16285368 | 0.67 | HTT (0.46) | MGLLHCAR1TDP1KDM4EAPOBEC3G | |
| SCHEMBL28644729 | 0.67 | MGLL (0.46) | MGLLNPBWR1MCHR1HCAR1POLB | |
| SCHEMBL18211463 | 0.64 | MGLL (0.62) | MGLLHCAR1POLBTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249163-B2 | PDE10a inhibitors for the treatment of type II diabetes | JANSSEN PHARMACEUTICA NV. (BE) | 2016-02-02 | — | — | US | disclosed |
| US-20140364414-A1 | PDE 10a Inhibitors for the Treatment of Type II Diabetes | JANSSEN PHARMACEUTICA, NV (BE) | 2014-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364414-A1 | PDE 10a Inhibitors for the Treatment of Type II Diabetes | PDE2A, PDE3B, PDE3A | MGLL 765/4885NPBWR1 2190/4885MCHR1 3792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.