Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | ESRRB | O95718 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524467 | 0.82 | ALDH1A1 (0.50) | ALDH1A1LMNAKDM4EAKT1MAPT | |
| SCHEMBL17361242 | 0.76 | ALDH1A1 (0.51) | ALDH1A1LMNAKDM4EAKT1MAPT | |
| Bromide SCHEMBL28529432 | 0.75 | ALDH1A1 (0.50) | ALDH1A1LMNAKDM4EAKT1MAPT | |
| SCHEMBL17385252 | 0.75 | ALDH1A1 (0.50) | ALDH1A1LMNAKDM4EAKT1MAPT | |
| SCHEMBL27065040 | 0.73 | LMNA (0.49) | ALDH1A1LMNAKDM4EMAPTKMT2A | |
| SCHEMBL13285868 | 0.73 | LMNA (0.49) | ALDH1A1LMNAKDM4EMAPTKMT2A | |
| SCHEMBL15132436 | 0.73 | LMNA (0.49) | ALDH1A1LMNAKDM4EMAPTKMT2A | |
| Bromide SCHEMBL5074991 | 0.72 | LMNA (0.48) | ALDH1A1LMNAKDM4EMAPTKMT2A | |
| Bromide SCHEMBL5075234 | 0.72 | LMNA (0.48) | ALDH1A1LMNAKDM4EMAPTKMT2A | |
| Phthalic Acid SCHEMBL28233805 | 0.72 | ALDH1A1 (0.58) | ALDH1A1LMNAKDM4EAKT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2398477-A1 | METHODS OF AND COMPOSITIONS FOR REDUCING CELL DEATH | Wisconsin Alumni Research Foundation (US) | 2011-12-28 | — | — | EP | claimed |
| US-7932239-B2 | Methods of and compositions for reducing neuronal cell death | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2011-04-26 | — | — | US | claimed |
| US-20100256093-A1 | METHODS OF AND COMPOSITIONS FOR REDUCING CELL DEATH | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-10-07 | — | — | US | claimed |
| WO-2010096778-A1 | METHODS OF AND COMPOSITIONS FOR REDUCING CELL DEATH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-08-26 | — | — | WO | claimed |
| US-20060258622-A1 | Methods of and compositions for reducing neuronal cell death | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-11-16 | — | — | US | claimed |
| US-8415327-B2 | Methods of and compositions for reducing cell death | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-04-09 | — | — | US | disclosed |
| EP-2398477-A1 | METHODS OF AND COMPOSITIONS FOR REDUCING CELL DEATH | Wisconsin Alumni Research Foundation (US) | 2011-12-28 | — | — | EP | disclosed |
| US-20110195931-A1 | METHODS AND COMPOSITIONS FOR REDUCING NEURONAL CELL DEATH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2011-08-11 | — | — | US | disclosed |
| US-7932239-B2 | Methods of and compositions for reducing neuronal cell death | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2011-04-26 | — | — | US | disclosed |
| US-20100256093-A1 | METHODS OF AND COMPOSITIONS FOR REDUCING CELL DEATH | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-10-07 | — | — | US | disclosed |
| WO-2010096778-A1 | METHODS OF AND COMPOSITIONS FOR REDUCING CELL DEATH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-08-26 | — | — | WO | disclosed |
| US-20060258622-A1 | Methods of and compositions for reducing neuronal cell death | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258622-A1 | Methods of and compositions for reducing neuronal cell death | CASP3, BAX, CASP9 | ALDH1A1 4149/4885LMNA 128/4885KDM4E 2878/4885 |
| US-20110195931-A1 | METHODS AND COMPOSITIONS FOR REDUCING NEURONAL CELL DEATH | CASP3, BAX, CASP9 | ALDH1A1 4172/4885LMNA 115/4885KDM4E 2570/4885 |
| US-20100256093-A1 | METHODS OF AND COMPOSITIONS FOR REDUCING CELL DEATH | BAX, CASP3, BCL2 | ALDH1A1 4139/4885LMNA 76/4885KDM4E 2985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.