Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | FADS1 | O60427 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16296350 | 0.81 | ALOX5 (0.47) | ALDH1A1GAAMAPTMGLLALOX5 | |
| SCHEMBL16296035 | 0.76 | NOTUM (0.40) | NOTUM | |
| SCHEMBL16296173 | 0.73 | DAO (0.33) | — | |
| SCHEMBL16296407 | 0.72 | GLA (0.35) | ALDH1A1L3MBTL1 | |
| SCHEMBL6270872 | 0.71 | ALDH1A1 (0.46) | ALDH1A1POLBGAAMAPTFAAH | |
| SCHEMBL17505102 | 0.69 | EP300 (0.46) | ALDH1A1GAAMAPTL3MBTL1IDO1 | |
| Hydrochloric Acid SCHEMBL19207894 | 0.68 | EP300 (0.45) | ALDH1A1GAAMAPTL3MBTL1IDO1 | |
| SCHEMBL17537374 | 0.67 | FAAH (0.59) | ALDH1A1POLBGAAMAPTFAAH | |
| SCHEMBL9645381 | 0.67 | ALDH1A1 (0.49) | ALDH1A1POLBGAAMAPTFAAH | |
| SCHEMBL9795564 | 0.66 | ALOX5 (0.56) | ALDH1A1POLBGAAMAPTFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3008055-A1 | NOVEL TETRAZOLONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-04-20 | — | — | EP | disclosed |
| WO-2014198592-A1 | NOVEL TETRAZOLONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-12-18 | — | — | WO | disclosed |