Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 4/20 | 0.49 |
| ▸ | MLYCD | O95822 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.39 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.37 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.37 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16296476 | 0.82 | MLYCD (0.49) | POLQMLYCDKMT2AKDM4ECHRM5 | |
| SCHEMBL21437132 | 0.81 | MLYCD (0.51) | POLQMLYCDKMT2AKDM4ECHRM5 | |
| SCHEMBL16296475 | 0.77 | MLYCD (0.48) | POLQMLYCDKMT2AKDM4ECHRM5 | |
| SCHEMBL14192258 | 0.73 | KMT2A (0.49) | POLQMLYCDKMT2AKDM4ECHRM5 | |
| SCHEMBL24435364 | 0.70 | KDM4E (0.46) | POLQMLYCDKMT2AKDM4ECHRM5 | |
| SCHEMBL481904 | 0.70 | KDM4E (0.58) | POLQMLYCDKMT2AKDM4ECHRM5 | |
| SCHEMBL4385687 | 0.70 | KMT2A (0.53) | POLQMLYCDKMT2AKDM4ECHRM5 | |
| Trifluoroacetic Acid SCHEMBL4705712 | 0.70 | POLQ (0.49) | POLQMLYCDKMT2AKDM4ECHRM5 | |
| SCHEMBL28057393 | 0.69 | POLQ (0.53) | POLQMLYCDKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL28427631 | 0.69 | LMNA (0.55) | POLQKMT2AKDM4ECHRM5CHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221801-B2 | Inhibitors of histone demethylases | EPITHERAPEUTICS APS (DK) | 2015-12-29 | — | — | US | disclosed |
| US-20140371214-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. | 2014-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371214-A1 | INHIBITORS OF HISTONE DEMETHYLASES | KDM1B, KDM1A, KDM3A | POLQ 750/4885MLYCD 2375/4885KMT2A 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.