Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 18/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16298326 | 0.77 | TGFBR1 (0.37) | TGFBR1MAPK14 | |
| SCHEMBL8238164 | 0.70 | TGFBR1 (0.57) | TGFBR1MAPK14 | |
| SCHEMBL8237983 | 0.70 | TGFBR1 (0.49) | TGFBR1MAPK14 | |
| SCHEMBL8229446 | 0.61 | TGFBR1 (0.58) | TGFBR1MAPK14 | |
| SCHEMBL8237303 | 0.58 | TGFBR1 (0.59) | TGFBR1 | |
| SCHEMBL11249151 | 0.58 | RAB9A (0.49) | KDM4EALDH1A1MAPTMAPK1HTT | |
| SCHEMBL20575652 | 0.57 | WDR5 (0.34) | TGFBR1ALDH1A1MAPTHTTL3MBTL1 | |
| SCHEMBL8182056 | 0.56 | WDR5 (0.41) | — | |
| SCHEMBL7136431 | 0.56 | DRD1 (0.46) | KDM4EALDH1A1MAPTMAPK1HTT | |
| SCHEMBL16385409 | 0.55 | CCR1 (0.48) | TGFBR1MAPK14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076127-A2 | CONDENSED IMIDAZOLES OR PYRAZOLES AND THEIR USE AS TRANSFORMING GROWTH FACTOR MODULATORS | BIOGEN IDEC MA INC (US) | 2007-07-05 | — | — | WO | disclosed |