Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13490406 | 0.71 | HRH2 (0.39) | ALDH1A1SMN1; SMN2MAPK1KMT2ALMNA | |
| SCHEMBL19459082 | 0.71 | USP30 (0.49) | MAPK1 | |
| SCHEMBL11195135 | 0.70 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2MAPK1KMT2ALMNA | |
| SCHEMBL9520830 | 0.68 | KMT2A (0.41) | ALDH1A1SMN1; SMN2MAPK1KMT2ALMNA | |
| SCHEMBL11450349 | 0.67 | MAPT (0.42) | ALDH1A1SMN1; SMN2MAPK1KMT2ALMNA | |
| SCHEMBL13490375 | 0.67 | RAB9A (0.46) | ALDH1A1SMN1; SMN2KMT2ALMNAMEN1 | |
| SCHEMBL9519404 | 0.67 | CHRM2 (0.46) | ALDH1A1KMT2A | |
| SCHEMBL9624898 | 0.66 | MAPT (0.44) | ALDH1A1SMN1; SMN2MAPK1KMT2ALMNA | |
| SCHEMBL19459096 | 0.66 | ESR2 (0.45) | ALDH1A1MAPK1LMNAMAPT | |
| SCHEMBL2420231 | 0.65 | CHRM3 (0.58) | ALDH1A1MAPK1KMT2ALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |