Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.37 |
| ▸ | GCGR | P47871 | 3/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16305975 | 0.92 | CTSS (0.40) | CTSSGCGRSLC6A5HRH3DDR1 | |
| SCHEMBL22384200 | 0.88 | CTSS (0.42) | CTSSGCGRACESLC6A5PSMB1 | |
| SCHEMBL16375225 | 0.88 | CTSS (0.42) | CTSSGCGRACESLC6A5PSMB1 | |
| SCHEMBL17834389 | 0.87 | RARB (0.39) | GCGRSLC6A5HRH2HRH1HRH3 | |
| SCHEMBL16294798 | 0.86 | CTSS (0.45) | CTSSGCGRDDR1MAPK14DDR2 | |
| SCHEMBL16294799 | 0.86 | CTSS (0.45) | CTSSGCGRDDR1MAPK14DDR2 | |
| SCHEMBL16306004 | 0.86 | ESRRG (0.40) | CTSSGCGRMEN1ALDH1A1KMT2A | |
| SCHEMBL16305727 | 0.81 | KLKB1 (0.41) | CTSSACEPSMB1PSMB8PSMB9 | |
| SCHEMBL22756160 | 0.79 | PSMB5 (0.39) | CTSSPSMB1PSMB8PSMB9PSMB5 | |
| SCHEMBL17834436 | 0.79 | RARB (0.42) | GCGRSLC6A5HRH3MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016094729-A1 | GLP-1 RECEPTOR MODULATORS | CELGENE INTERNATIONAL II SARL (CH) | 2016-06-16 | — | — | WO | disclosed |
| WO-2014201172-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | RECEPTOS, INC. (US) | 2014-12-18 | — | — | WO | disclosed |