Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 9/20 | 0.58 |
| ▸ | MMP2 | P08253 | 6/20 | 0.58 |
| ▸ | MMP14 | P50281 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23749652 | 0.81 | MMP13 (0.57) | MMP13MMP2MMP14KDM4EALDH1A1 | |
| SCHEMBL30216943 | 0.81 | MMP13 (0.57) | MMP13MMP2MMP14KDM4EALDH1A1 | |
| SCHEMBL13944380 | 0.78 | QDPR (0.51) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4185793 | 0.77 | QDPR (0.50) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL27982263 | 0.76 | QDPR (0.48) | FGFR1FGFR2FGFR3 | |
| SCHEMBL419130 | 0.76 | MMP13 (0.77) | MMP13MMP2MMP14KDM4EALDH1A1 | |
| SCHEMBL17109184 | 0.76 | KDM4E (0.52) | MMP13MMP2MMP14KDM4EALDH1A1 | |
| SCHEMBL31424332 | 0.75 | MMP13 (0.55) | MMP13MMP2MMP14KDM4EALDH1A1 | |
| SCHEMBL31424468 | 0.75 | MMP13 (0.55) | MMP13MMP2MMP14KDM4EALDH1A1 | |
| SCHEMBL23776847 | 0.75 | CDK9 (0.45) | MMP13MMP2MMP14KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014199933-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | アステラス製薬株式会社 (JP) | 2014-12-18 | — | — | WO | disclosed |