Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.44 |
| ▸ | MTOR | P42345 | 9/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16331460 | 0.89 | MAPT (0.47) | PIK3CAMAPTTP53PRKDCMEN1 | |
| SCHEMBL16331626 | 0.86 | GABRG2 (0.52) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16331800 | 0.84 | SMN1; SMN2 (0.44) | MAPTTP53MEN1KMT2AALDH1A1 | |
| SCHEMBL16331319 | 0.82 | FYN (0.47) | MAPTTP53MEN1KMT2AALDH1A1 | |
| SCHEMBL16332572 | 0.82 | PIK3CA (0.48) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16331495 | 0.82 | CYP1A2 (0.53) | PIK3CAMTORMAPTPRKDCMEN1 | |
| SCHEMBL16332496 | 0.82 | GABRG2 (0.47) | MAPTTP53PRKDCMEN1KMT2A | |
| SCHEMBL16331764 | 0.81 | PPARG (0.42) | MTORMAPTTP53LMNACYP1A2 | |
| SCHEMBL16331443 | 0.81 | RHOA (0.51) | MAPTTP53MEN1KMT2AALDH1A1 | |
| SCHEMBL16332454 | 0.81 | L3MBTL1 (0.44) | MAPTTP53MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |