Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.43 |
| ▸ | MTOR | P42345 | 4/20 | 0.43 |
| ▸ | PRKDC | P78527 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332047 | 0.91 | PIK3CA (0.46) | PIK3CAMTORPRKDCMAPK1ALOX15 | |
| SCHEMBL16332003 | 0.86 | CYP1A2 (0.55) | PIK3CAPRKDCMAPK1ALOX15MAPT | |
| SCHEMBL16332508 | 0.85 | ALDH1A1 (0.45) | MAPK1ALOX15MAPTNPC1RAB9A | |
| SCHEMBL16331539 | 0.85 | PIK3CA (0.47) | PIK3CAMTORPRKDCMAPK1ALOX15 | |
| SCHEMBL16332345 | 0.84 | RAB9A (0.46) | MAPK1ALOX15MAPTNPC1RAB9A | |
| SCHEMBL16331599 | 0.84 | PIK3CA (0.44) | PIK3CAMTORPRKDCMAPK1ALOX15 | |
| SCHEMBL16332431 | 0.82 | RHOA (0.46) | MAPK1ALOX15MAPTNPC1RAB9A | |
| SCHEMBL16333060 | 0.80 | PIK3CA (0.50) | PIK3CAMTORPRKDCMAPTGAA | |
| SCHEMBL16332406 | 0.79 | SMN1; SMN2 (0.54) | MAPK1ALOX15MAPTNPC1RAB9A | |
| SCHEMBL16332326 | 0.78 | GABRG2 (0.52) | PIK3CAMTORPRKDCMAPK1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |