Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.63 |
| ▸ | FBP1 | P09467 | 1/20 | 0.48 |
| ▸ | SLC40A1 | Q9NP59 | 6/20 | 0.45 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.45 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.43 |
| ▸ | CKS1B | P61024 | 3/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 3/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633740 | 0.85 | HTR6 (0.76) | HTR6FBP1SLC40A1 | |
| SCHEMBL1635145 | 0.78 | HTR6 (0.77) | HTR6FBP1KMT2AKEAP1NFE2L2 | |
| SCHEMBL1633816 | 0.78 | HTR6 (0.77) | HTR6FBP1 | |
| SCHEMBL1635040 | 0.78 | HTR6 (1.00) | HTR6FBP1KMT2A | |
| SCHEMBL1635033 | 0.75 | HTR6 (0.72) | HTR6KEAP1NFE2L2 | |
| SCHEMBL1634443 | 0.74 | HTR6 (0.63) | HTR6FBP1JAK2JAK1TYK2 | |
| SCHEMBL25140692 | 0.71 | ACLY (0.52) | SLC40A1GLO1 | |
| SCHEMBL30806174 | 0.71 | ACLY (0.52) | SLC40A1GLO1 | |
| SCHEMBL789565 | 0.71 | PIK3CA (0.57) | SLC40A1GLO1BRAFKEAP1NFE2L2 | |
| SCHEMBL1207409 | 0.70 | SLC40A1 (0.62) | SLC40A1GLO1CKS1BSKP2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247595-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-07-20 | — | — | EP | disclosed |
| US-7932254-B2 | Pyrrolopyrazine kinase inhibitors | Roche Palo Alto (US) | 2011-04-26 | — | — | US | disclosed |