Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 6/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16338926 | 0.82 | SCN10A (0.35) | CCR5KCNH2SLC6A9 | |
| SCHEMBL16338927 | 0.74 | CYP11B1 (0.32) | TTR | |
| SCHEMBL16338929 | 0.73 | PTGER4 (0.43) | TTR | |
| SCHEMBL353204 | 0.64 | KDM4E (0.40) | CCR5KCNH2SLC6A9 | |
| SCHEMBL4784806 | 0.63 | ALDH1A1 (0.42) | — | |
| Hydrochloric Acid SCHEMBL4249059 | 0.62 | KDM4E (0.39) | CCR5KCNH2SLC6A9 | |
| SCHEMBL9504653 | 0.62 | KDM4E (0.39) | CCR5KCNH2SLC6A9 | |
| SCHEMBL25389487 | 0.62 | KMT2A (0.40) | — | |
| SCHEMBL31590723 | 0.61 | USP2 (0.43) | — | |
| SCHEMBL30686207 | 0.61 | PRKCQ (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921555-B2 | Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones | MERCK SHARP & DOHME CORP. (US) | 2014-12-30 | — | — | US | disclosed |