Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 5/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2130721 | 0.76 | GABRP (0.50) | PTGER4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2132966 | 0.75 | GABRP (0.49) | PTGER4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5205369 | 0.74 | PRKCA (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL16338928 | 0.73 | CCR5 (0.32) | TTR | |
| SCHEMBL2130484 | 0.72 | PKM (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL12983454 | 0.71 | PTGER4 (0.42) | PTGER4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5205003 | 0.69 | PRKCQ (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL12983811 | 0.67 | GABRP (0.43) | PTGER4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30572289 | 0.66 | IKBKB (0.45) | ALDH1A1KDM4ECYP3A4HSD17B10HRH3 | |
| SCHEMBL12984367 | 0.66 | GABRP (0.42) | PTGER4GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921555-B2 | Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones | MERCK SHARP & DOHME CORP. (US) | 2014-12-30 | — | — | US | disclosed |